27 results
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
Primary Objectives:- Evaluate changes in the immune system upon exposure to FVIII in patients with severe hemophilia A - Identify immunologic predictors of FVIII inhibitor development or tolerance
To define the role of genetic variations in SNARE protein genes in the regulation of VWF plasma concentrations and their effect on other substances secreted by WPBs and alpha-granules and coagulation parameters under physiological circumstances.
The aim of the study is to understand the effects of CPB on coagulation and fibrinolysis to improve treatment of excessive blood loss (>2L/24 hours or >200 mL/hour) after cardiac surgery.The objective of this study is to differentiate…
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
The primary objective of this study is to establish a panel of markers that can be used for further research into the understanding of the pathogenesis of PTS.
The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.
In this study, we will assess whether healthy men with high-normal serum CK display attenuated platelet aggregation, compared to those with low-normal serum CK.
The aim of this study is to characterize the early immune response against F VIII concentrates in patients with severe hemophilia A before and during inhibitor development.
Inflammatory and endothelial parametersTo investigate the influence of factor VIII concentrate infusion on inflammatory and endothelial parameters in patients with severe hemophilia A.Platelet activity and responsivenessTo investigate the influence…
The aim of this study is to evaluate fibrinogen concentrations, coagulation and fibrinolysis during and after CABG, to characterize the ex vivo effects of rhFGN variant Aα610 (wild type) and Aα847 when added to blood samples collected after CABG,…
2.1 Primary Objective• Evaluation of the levels of thrombophilic factors in the blood of HIV-infected patients before starting with cART and the changes of these levels when on cART for the time of one year. 2.2 Secondary Objective• Evaluation of…
To find procoagulant markers predictive of progression of the underlying malignancy or predictive of the occurrence of a venous thrombotic event.
To explore the effects of acute fear on the coagulation system while sitting still.
The influence of Annexin A2 SNP (rs17845226) on von Willebrand factor secretion by endothelial cells
The aim of this research is to study the effect of Annexin A2 SNP rs17845226 on vWF secretion by endothelial cells of controls carrying different Annexin A2 SNP rs17845226 genotypes (WT, homozygous, heterozygous). By testing several endothelial cell…
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
To assess whether the inhibitory effect of CK on platelet aggregation can be reversed in vitro.
Our primary aim is to investigate the current bleeding tendency of patients with VWD.
Primary Objective: - to establish if a gut microbiome perturbation affects APS disease phenotype.Secondary Objective(s): - to identify biomarkers that are responsive gut microbiome perturbation.- to establish if gut microbiome perturbation affects…
Primary Objective:Improve the knowledge about the immune response during FVIII/FIX replacement therapy in patients with haemophilia A and B respectively. This involves both the mechanism of: 1) primary tolerance induction to FVIII/FIX in previously…