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Blood donation for experimental in vitro research

Sample collection for in vitro research

Profiling bone marrow from kidney transplant recipients

Previous studies have shown that the origin of trained innate immunity lies in the bone marrow and is determined by epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells. In this study, we investigate whether long-term…

A longitudinal prospective, observational, cohort study in lactating mothers and their newborns to further unravel the complexity of human milk

The objective of this study is to further unravel the complexity of human milk and its variations over lactation stages and between individuals.

PARASOL

Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…

Stress-induced immune reprogramming in cardiovascular disease (STRESS-CVD)

To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.

Prospective study to evaluate trained immunity in kidney transplantation

In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…

Image-based remote monitoring in cardiac surgery patients: FORSEE 3 trial

Main objective: 1. Determine the feasibility, in terms of system fidelity and acceptability, of remote, image-based monitoring in cardiac surgery patients on a general ward. Secondary objectives: 1. The validity of remote, image-based heart- and…

COgnitive Dynamics in Early Childhood

2 OBJECTIVES2.1 Primary Objective: To address the existing knowledge gaps and advance our understanding of cognitive variability, the CODEC study aims to integrate experience sampling methods, longitudinal designs, deep phenotyping cohorts, and…

Model Informed preciSion doSIng tO iNdividualise and optimize pharmacotherapeutic treatment (MISSION) - Appendix 1: Prospective evaluation of Model informed precision dosing (MIPD) for tacrolimus and mycophenolic acid in paediatric patients with a kidney disease

Overall objective:To improve the existing drug prescribing and treatment monitoring process.Objective appendix 1: To prospectively evaluate the predictive performance of the MIPD strategy for tacrolimus and mycophenolic acid in paediatric patients…

Analysing cEllular bioenergetics aNd structural aDaptations in the qUadriceps muscle befoRe and After endobroNChial valve treatmEnt.

To investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in response to EBV treatment.

The 10-year follow-up of the ESCAPE trial: Do patients with a non-obstructive meniscal tear develop more knee osteoarthritis after knee surgery or after exercise therapy?

To compare the degree of osteoarthritis in the knee after 10 years, in patients with non-obstructive meniscal tear, between meniscal surgery and exercise therapy treatment.

Assessment of music by people with hearing impairments

The main objective is to assess the perceived sound quality of different speech and music excerpts that are modified using the dereverberation algorithm by CI users. To this end a suitable graphical user interface (GUI), the MuSHRA, will be…

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial

This study is to investigate the safety and effectiveness of the AeriSeal system in limiting collateral ventilation within a target lung lobe. And to achieve lung volume reduction using Zephyur Vavles and assess lung function, hyperinflations and…