313 results
The main objective of this study is to gain more insight into the working mechanism of static magnetic fields alone, as well as in combination with movement-induced time-varying magnetic fields near MRI-scanners on neurocognitive and vestibular…
The objective of the present study is to determine the sensitivity of the tests used in different fields of expertise for the dose-effects of alcohol.
Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…
Based on our hypothesis that orally ingested inulin is fermented into different SCFAs, and these SCFAs can have beneficial metabolic effects, we aim to address the following primary objective: To investigate the human metabolic effects of SCFA…
To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected subcutaneously by jet-injection to that of the same insulin injected with a conventional pen in the management of…
We propose to conduct a study in healthy subjects where a serotonergic challenge is given in a placebo-controlled, crossover fashion. Before each challenge, participants will be measured 1 time to define their baseline resting state networks (RSNs)…
The purpose of the study is to evaluate the adhesiveness of two different patch formulations of rotigotine. This study is not intended to improve the health, but is necessary for the further development of the rotigotine patches
The effect of different flour compositions in a carbohydrate food product on exogenous and total blood glucose.
The aim of this project is to validate the hypothesis that intranasal insulin improves development and behaviour in children with Phelan-McDermid syndrome.
To investigate if there is a clinically important different effect of atropine on haemodynamic variables, tissue oxygenation or microcirculation during anaesthesia with either sufentanil and propofol or with remifentanil and propofol.
The primary objective of this study is to measure the effect of a psychopharmacological manipulation of NE on fMRI measures of the fidelity of cortical representation.The secondary objective is to determine if increased levels of cortical…
The aim of this study is to investigate the effect of different doses of vitamin D on postprandial leukocyte activation markers, oxidative stress and arterial stiffness in vitamin D deficient females.
The aim is to assess if people can perceive if the exposure-unit is on or off.
Based on our hypothesis that differential availability of SCFA will have beneficial effects on substrate and energy metabolism, the following objectives will be addressed:In this pilot study we will validate whether rectal administration of SCFA is…
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a high hydrocortisone dose. In addition, quality of life, metabolic profile and somatosensation will be described…
The current research proposal is designed to assess the influence of cocaine on creativity.
Compare sensitivity and specificity of both rules as well as compare the accuracy between observer groups for these rules. Also the interobserver agreement is assessed to test whether the rules are reproducible.
The primary objective of this study is to determine the effects of aliskiren, as compared to ramipril, on renal hemodynamics in overweight/obese and hypertensive patients.
To compare one dose of the short acting tropicamide combined with one dose of the longer acting cyclopentolate (c+t) with a double dose of the longer acting cyclopentolate (c+c). To develop a cycloplegics protocol that garantees optimal refractieve…
The primary objective of the present study is to investigate the postprandial effect of arginine-rich protein (i.e. pea-protein) on metabolic control, inflammation and endothelial function after a high-fat meal in subjects with the metabolic…