40 results
This is a phase I/II pediatric dose-ranging study that will evaluate the safety, tolerability and pharmacokinetics of midostaurin in children <18 years of age and >= 3 months who have relapsed or refractory leukemias that may benefit…
The primary objective of this study is to determine the freedom from local failure in patients alive at 1 year
This study is designed as an extension study to the proof-of-concept trial CAIN457A2209 in patients with ankylosing spondylitis and aims to provide continuous treatment with AIN457 for patients in the core trial, to obtain safety and tolerability…
To evaluate the probability that the progression free survival (PFS) in the first-line treatment with RAD001 is non-inferior to the first-line treatment with sunitinib for patients with metastatic renal cell carcinoma (primary objective).…
To evaluate the safety and effecacy of the Lung Volume Reduction Coil to improve QOL pulmonary function for emphysema subjects with severe hyperinflation.
A consistent finding in many studies in patients with operable esophageal and gastro-esophageal junction (GEJ) cancer is that response to preoperative therapy, particularly the absence of residual disease in the surgical specimen, is an indicator of…
The objective of the study is to answer the following questions:a) Does the PLS-strategy improve pitch- and speech-perception?b) How does the number of harmonics in consecutive channels influence frequency discrimination, in speech coding strategies…
This study is designed as an extension study to the proof-of-concept trial CAIN457A2206 in patients with psoriatic arthritis and aims to provide continuous treatment with AIN457 for patients in the core trial, to obtain safety and tolerability…
1. To evaluate efficacy of vorinostat in the treatment of patients with polycythaemia vera (PV) and essential thrombocythaemia (ET) 2. To evaluate if vorinostat as monotherapy of patients with PV and ET is followed by a decline in clonal…
To develop a simplified HALO90 ablation protocol at the same energy level and with compared efficacy and safety as the current protocol.
Primary objective:Phase 1b:-To evaluate the safety and tolerability of escalating doses of mapatumumab in combination with cisplatin and radiotherapy in subjects with locally advanced cervical cancer.Phase 2:-To evaluate the efficacy of mapatumumab…
The primary objective of this study is to determine the progression-free survival (PFS) rate assessed 12 weeks after the initiation of IMC-A12 monotherapy, administered every 2 weeks to patients with previously-treated, advanced or metastatic soft…
1 to describe the long term effects of FGT and mutual support among first-degree relatives and spouses of suicide victims.2 inventarisation of help seeking behaviour of first-degree relatives and spouses of suicide victims during the first year…
Primary outcome:The effect of Pyridostigmine (cholinesterase inhibitor) on inflammatory signs as pain, temperature and swelling of the extremity measured according to TREND protocol (appendix 1).Pain is measured according to VAS scale, temperature,…
To assess the therapeutic activity of SU11248 in patients with exptensive disease small cell lung cancer who are either chemonaive or have a sensitive relapse
Objective is to monitor muscle function before and after a solitary transfer of the pectoralis major for patients suffering a winged scapula. Clinical results, assessed in terms of pain experience, maximal Range of Motion, arm force and arm function…
This research project is directed at assessing tumor response to radiotherapy. The goal of the study is to develop a gene expression profile that predicts response to radiotherapy in early breast cancer patients, allowing for optimal treatment…
The objective for this study is twofold. The primary objective of the present study is to assess efficacy of DBS in the nucleus accumbens for patients with refractory MDD. Secondary objectives are the evaluation of long term efficacy and…
The primary objective of this second phase study is to estimate the occurrence of anastomotic leakage when the C-seal is used.Secondary objectives are:* Feasibility of applying the C-seal, especially considering the improved attachement to the…
In this study we want to evaluate the safety, technical efficiency, and volume treatment capabilities of the Philips MR guided HIFU system in the treatment of patients with symptomatic uterine fibroids. This information is required for CE labelling…