46 results
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
1. To determine biomarkers of response and non-response to treatment for active SLE in a prospective study where patients will be allocated to therapy according to current clinical practice and the EULAR guidelines (response biomarker study; 3TR SLE…
The aim of this project is to characterize the composition and activity of lymphocytes immune cell subsets and cholangiocytes in active inflammation in the central/extrahepatic bile ducts through surface markers and an in-depth transcriptomic…
In this research proposal, we aim to develop chemical reporter molecules to study neutrophil activity and NET formation in real-time. We will systematically study the effect of brain-associated amyloid fibrils on NET formation and investigate the…
To identify novel (causal) risk factors, including biomarkers and genetic determinants for disease progression and (severe) diabetes complications in people with T2D, in order to develop new, more targeted and effective therapies that will improve…
To evaluate post-operative neurologic damage using clinical data on delirium and neuropsychological testing for long term postoperative decline, in combination with measures of NfL, GFAP and Tau in CTEPH patients treated with PEA or BPA in the…
As highlighted, significant gaps in knowledge remain regarding etiology of cough, consequences of cough and appropriate treatment of cough in patients with pulmonary fibrosis. A further understanding of the similarities and differences in cough…
The general objective of this study protocol is to add another follow-up measurement, round 8, to the Doetinchem cohort study, 6 years after round 7, and 36 years after round 1 This contributes to an infrastructure of data to tackle research…
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…
Previous studies have shown that the origin of trained innate immunity lies in the bone marrow and is determined by epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells. In this study, we investigate whether long-term…
Primary Objective: Identify markers that distinguish between high and low rupture risk IAs.Secondary Objective(s): • Gain insight in the hemodynamic and cellular processes underlying IA rupture risk.• Determine the interrelatedness of hemodynamic…
The primary objective of our study is to evaluate sensation (static/moving pressure/touch, hot/cold temperature and pain threshold) of the face in patients with unilateral facial nerve palsy and compare the sensation of the affected side to the non-…
Primary Objective:Part 1: to characterize platelets of patients with Lowe syndrome using superresolution microscopy.Part 2: to characterize platelet age in patients receiving chemotherapy for AML using artificial intelligence techniques.Secondary…
To study the human adult cochlea, in specific it*s RNA and protein expression patterns and morphology.
Assess nutrition-related biomarkers in plasma and urine samples at ICU admission
The primary objective is to validate the LSCI against the LDPI in the assessment of the forehead DBF induced by capsaicin application and saline iontophoresis.
This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.
To assess the association between the presence of neutrophil subsets (CD16dim/CD62Lbright and CD16bright/CD62Ldim) and physical activity, physical fitness and complications in patients with esophageal or stomach cancer during curative treatment