329 results
The Municipal Health Service The Hague and the LUMC are planning to conduct a study similar to the one in Pune in The Hague. In the start-up phase of this study we are preparing a pilot study in which we will study anthropometry and insulin…
To study tumor oxygenation in woman with cervical carcinomaPrimarily: To study the feasibility of measuring tissue pO2 with the FDA approved Eppendorf needle electrode and to correlate these results with promising new non-invasive methods to measure…
1. To invest the prevalence of bacterial overgrowth in the elderly who undergo an diagnostic gastroscopy.2. After investigating the number of microorganisms in the aspirate the probable correlation will be established between the complaints of the…
The challenging aim of this three-year STREP project is to breakthrough with research that addresses the needs of those with dementia, particularly those with mild dementia in Europe. At about 2% of the elderly population, this comes to around 1,900…
Objectives to explore: :1-whether kinase activities can be detected in lymphocytes derived from cancer patients, using a peptide array or a phosphopeptide capture SELDI-TOF MS assay.2-how many cells are needed for the generation of a kinase activity…
Primary objectivesTo establish the safety and tolerability of1. two doses of bevacizumab 7.5 mg/kg administered every 3 weeks with concurrent thoracic radiotherapy to 66 Gy;2. concurrent (7.5 mg/kg) and maintenance (15 mg/kg) bevacizumab during, and…
Aim of the study is to describe and evaluate an alternative physical therapy management program in patients with a complex regional pain syndrome type 1. A secondary aim is to describe the adverse effects that occur during or after the intervention.
To determine the frequency of symptoms and signs of a neuromuscular disorder (myopathy, neuropathy) in patients with haemochromatosis. To evaluate in these patients the impact of these symptoms and signs on the quality of life. To assess in patients…
The objective of this feasibility study is to demonstrate that the device is safe and potentially efficacious for use in patients undergoing high risk Percutaneous Coronary Interventions (PCI).
A. To determine prevalence and determinants of impaired glucose regulation 1. To study the prevalence of impaired glucose regulation and type 2 diabetes in the general population aged 40 to 65 years, and to compare these prevalence rates with those…
In both MG and MS patients groups we expect to find signs of central fatigue. The contribution of central fatigue to the general feeling of fatigue is expected to be more pronounced in MS-patients than in MG-patients. The secondary effects of motor…
To quantify the motion of the seminal vesicles.
The purpose of this study is to determine if the development of idiopathic scoliosis is related to neuropathic detrusor/sphincter dyssynergia. When bladder and sphincter function are disturbed, adequate therapy can be started in an early phase to…
The main goal of this study is to evaluate the effectiveness of the NESS L300 on walking skills, as compared to a conventional ankle-foot orthosis, in stroke patients with a drop foot.
The main goal of neoadjuvant therapy should be a pathological complete response (pCR), because pCR more accurately predicts improved patient outcome and prolonged survival. In the present study, pathological response will be evaluated by The Miller…
1. To what extend does hypoxia occur in cervical cancer and what is the intra- and intertumor heterogeneity?2. To what extend does proliferation occur in cervical cancer and what is the intra- and intertumor heterogeneity?3. Does co-localization of…
Aim of the present study is to test the hypothesis tha during inflammatory episodes there is a decline in lean body and fat mass and that this results in an increase in extracellular volume in dialysis patients because dry weight is not or…
Primary objectives:To determine the objective tumor response (CR + PR) after 3 weeks of erlotinibSecondary objectives: To describe predictive markers for response:- radiological response (FDG-PET/CT)- EGFR mutations (HER1)To determine (diseasefree)…
The objective of the current study proposal is to gain insight in the effect of pulmonary vein isolation on the electrophysiological properties nearby the ablation lines on the posterior sight of the left atrium and further away, especially in the…
1. The central hypothesis of this study is that genetic polymorphisms in drug metabolising enzymes and regulators of enzyme expression may predispose to ATDH. We propose to evaluate the presence of genetic polymorphisms among TB patients in…