72 results
PrimaryEffective treatment regimes and preventive tools of SIB in CdLS by studying phenomenology, etiology and pathogenesis.Secondary a. Development of a flow chart for daily care (diagnostics; management) b. Evaluation whether the present study can…
The aim of this research is, following the aforementioned theoretical framework, to investigate whether the two candidate genes in combination with EEG and fMRI markers differentiate between children that do and do not show a clinical response to…
To improve diagnostic tools for food/cashew nut allergies with the use of Mediator Release Assays.Genetic component of cashewnut allergy.
In Phase 1 of the project, a systematic approach will be used to identify which factors add to the prediction of children*s clinical risk status. First, we will determine how well multiple assessments of behavioral problems (opposition, aggression,…
1) To study the late effects of 131-I treatment and TSH suppressive therapy as well as quality of life in patients with childhood-onset DTC. 2) To determine the presence of RET/PTC 1 and 3 translocations and BRAF mutations, and to investigate their…
To evaluate the long-term safety and tolerability of pregabalin in pediatric subjects 1 month through 16 years of age with partial onset seizures and pediatric and adult subjects 5 to 65 years of age with (PGTC) seizures.
-Assess the incidence of major bleeding and clinically relevant non-major bleeding -Assess the incidence of recurrent venous thromboembolism -Characterize the pharmacokinetic/ pharmacodynamic profile of a 30-day treatment with oral rivaroxaban
Here we propose that in order to identify causal mechanisms that explain AD/HD-related heterogeneity, an integrative approach is needed. Therefore, in this project we will study the interaction between motivation and executive function in AD/HD and…
To evaluate the prevalence of femoral head pathology in patients with MPS III.
The objective of the current study is to determine and describe the level of physical fitness and the level of physical activity in Dutch children and adolescents after burn injury. With this a scientific fundament can be established for further…
To evaluate the safety and efficacy of solifenacin succinate suspension once daily in children and adolescents with OAB.
The aim of this study is to identify genetic defects underlying CHD and aortic aneurysms. This will provide insight in the aetiology and heredity of these diseases.
- To establish the 24-hour baseline profile of endogenous saliva melatonin concentrations and urine 6-SMT excretion in children aged 2 up to and including 17 years with neurodevelopmental disorders with sleep disturbances . - To establish the…
Obtain information regarding the movement abilities and muscle strength in persons with several neuromuscular diseases, which can be used to develop a motion controlles arm suport for daily use and training of arm function.
Objectives: The primary objective is to establish whether expiratory VOC analysis by electronic nose and GC-MS can: Ia) discriminate between patients (CF, PCD) with and without an exacerbation and Ib) discriminate between different microbial species…
The proposed longitudinal study aims to examine1) if the onset of type 1 diabetes before vs. during puberty results in different outcomes of glycaemic control, self management, psychological functioning and diabetes-related QoL2) how the development…
- To evaluate the demographic, clinical and genetic characteristics of all known patients with a diagnosis of cystinuria and cystine nephrolithiasis in the Netherlands.- To evaluate the relationship between genotype and phenotype of all known…
Main objective of the current study is to evaluatie clinical, laboratory and genetic risk factors associated with prograssion of neurological damage. The final objective is to make a prognostic model of these risk factors to predict early…
this study aims to evaluate the clinical value of ASL in the clinical MRI protocol of children with a brain tumor. To serve the sample size calculation, its primary objective is to assess whether there is a correlation between perfusion of (parts of…
The goal of this pilot family study is to test the feasibility of a family study in which both genetic and behavioral measures are studied. We hope to shed more light on the genetic factors and environmental influences that play a role in the…