304 results
Muscle hypoxia, either chronic or intermittent (exercise-induced), is responsible for the altered muscle oxidative phenotype in chronic obstructive pulmonary disease and chronic heart failure through modulation of the regulatory molecules PGC-1/…
Addittional training of teachers will result in greater effect-sizes for a school-based child intervention program for childhood behavior problems. Assessment of stepped-care child, teacher and parent intervention.
We hypothesise that the Taperloc BoneMaster coated stem is equal or better than conventional porous coated or cemented stem focussing on implant ingrowth and bone remodelling.
An intensive rectal wash-out program for constipated girls with NNBSD is as effective in curing recurrent urinary tract infections as cognitive bladder training in standard outpatient treatment.
Recent experimental and clinical data showed that the noble gas helium protects against myocardial reperfusion injury in rabbits in vivo and induces late preconditioning in rat hearts. It has also been demonstrated that another noble gas, xenon, can…
Early, aggressive treatment of rheumatoid arthritis with DMARDs has been proven to lower disease activity and suppress radiologic progression. Moreover, combination therapy is shown to be superior to monotherapy. The COBRA therapy is effective in…
The nutritional supplementations of prebiotics and synbiotics are effective in prevention and treatment of the symptoms of infections in infants.
1. Childhood cancer patients who follow the QLIM intervention program will: a. achieve significantly higher levels of physical fitness after the 12 week intervention compared to patients in the control group, as assessed by objective performance…
Prospective study determing whether MRI-Diffusion Weighted Imaging (DWI) and biomarkers in CSF have prognostic capabilities in patients with Spinal Cord Injury (SCI).
The null hypothesis of this research is that the ZCQ outcome of PDI surgery is similar to the ZCQ outcome os surgical decompression at 1 year after surgery.
- Epilepsy patients with brain tumours show altered functional connectivity and networks in the brain compared to healthy controls - Connectivity and networks change over time as a function of treatment
Inhibition of the H1 receptor will lead to an improvement of rectal sensitivity, followed by less abdominal symptoms in patients with irritable bowel syndrome.
Due to surgery and radiotherapy lymph drainage pathways in recurrent breast cancer could be altered. These aberrant drainage pathways could be detected with lymphatic mapping and sentinel node biopsy leading to a more thorough staging and possible…
Computerized decision support (CDSS) for tailoring prevention to the local circumstances using the guidelines of the Dutch college of general practitioners has impact on preventive activities in the primary care setting
Outpatient LMHW treatment in patients with objectively proven non-massive pulmonary embolism is efficacious and safe.
1) structured screening of problems in bringing-up and development of young children with a house call detects more children with high or intermediate risk of problems in bringing-up and development than structured screening performed at the child…
Improvement of the RV function by pulmonary valve replacement will result in improvement of RV dyssynchrony in corrected tetralogy of Fallot patients
Only 30% of patients, who are treated with antihypertensive drugs, reach target blood pressure levels. Noncompliance is considered to be an important cause of this lack of response to medication. In usual care, patients who do not respond to their…
Microalbuminuria in diabetes mellitus is not only associated with progression to renal disease, it is also a potent predictor of cardiovascular disease and thus may reflect widespread vascular damage. Endothelial dysfunction is one of the first…
The primary aim is to determine if there is a difference between tibolone and placebo or if there is a difference between raloxifene and placebo. The secondary aim is to determine if there is a difference between tibolone and raloxifene. Primary…