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WGS Implementation in standard cancer Diagnostics for Every cancer patient

The WIDE project aims to investigate if implementation of WGS in molecular diagnostics is feasible in routine practice at the Netherlands Cancer Institute (NKI).

The implications of discussing uncertainty in cancer genetic counseling about multigene panel testing for (analogue) patients* cognitive and affective outcomes.

This study aims to examine the effects of different manners in which counselors communicate uncertainty and respond to counselees* uncertainty, on analogue patients* affective and cognitive outcomes. In addition, the results of this study are used…

The Role of microbial produced ethanol in etiology of Non-Alcoholic Steatohepatitis (ETHANASH trial)

To investigate whether microbial produced ethanol plays a role in the development of NASH.

Validity, reliability, and usability of a foot temperature measuring system for high-risk diabetic patients
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The objectives are to determine the validity and reliability and the usability in the home environment of the foot temperature measuring system in hig-risk diabetic patients

Measuring muscle size and muscle quality in healthy adults: validity and reliability of ultrasound measurements using a curved-array transducer.
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This study aims to investigate the validity and reliability of US to measure muscle size and muscle quality in healthy adults compared to MRI/MRS.

Long term effect of definitive chemoradiotherapy on respiratory function tests in patients with locally advanced (non)-small cell lung carcinoma

The aim of the study is to evaluate the change of lung function at least one year after definitive chemoradiation (concurrent or sequential) or radiotherapy alone in patients with locally advanced (non) small cell lung carcinoma to assess late…

Measuring brain activity associated with visual recognition
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This serves three goals: i) to gain insight into the neural foundations of vision, ii) to develop pointers towards better and more efficient ways to diagnose ocular and neurological disease at an early stage, iii) to understand perceptual learning…

Targeted hypothermia vs. targeted normothermia after out-of-hospital cardiac arrest, a randomised clinical trial

We designed the study to test the hypothesis that post-ischaemic hypothermia, when compared tonormothermia and early treatment of fever, decreases mortality and improves neurologic functionin unconscious adults after out-of-hospital cardiac arrest.…

*Randomized controlled prospEctiVe trial comparing extended-release with immediate-release tacrOlimus; reducing calcineurin inhibitor related toxicity in LUng TransplantatION patients*

Primary Objective: to show a reduction in eGFR decline in patients treated with LCP tacrolimus compared to IR tacrolimus. Secondary objectives will include investigating the potential decline in other known side effects of calcineurin inhibitors i.e…

The effect of lidocaine infusion on ad libitum food intake and satiety in healthy volunteers

We hypothesize that intragastric infusion of lidocaine will result in a delay of postprandial satiation and hereby an increase in food intake at an ad libitum meal. Furthermore, we hypothesize that lidocaine infusion will not result in an increase…

A Phase 3 Multicenter, Randomized, Double-Masked Study Comparing the Efficacy and Safety of Emixustat Hydrochloride with Placebo for the Treatment of Macular Atrophy Secondary to Stargardt Disease

To determine if emixustat hydrochloride (emixustat) reduces the rate of progression of macular atrophy (MA) compared to placebo in subjects with Stargardt disease (STGD)1. To evaluate the safety and tolerability of emixustat compared to placebo2. To…

ReachPR Trial: Restoration of AV coupling by Cardiac Resynchronization Therapy in heart failure patients with prolonged PR interval

The purpose of this study is to investigate the acute hemodynamic effects of restoration of AV coupling by atrio-biventricular pacing in patients with HF and prolonged PR interval.

L-C LIGAMENT® VERSUS HAMSTRING AUTOGRAFT FOR PRIMARY ACL RECONSTRUCTION: A PROSPECTIVE, RANDOMIZED CONTROLLED TRIAL
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To assess performance and safety of L-C Ligament® against autograft surgery with hamstring tendon for primary ACL reconstruction.