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From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…

Improving the diagnosis and treatment of patients with head and neck squamous cell carcinoma: collection of tumor tissues ;The *HNcol* study

Objective:The aim of our study is to obtain a collection of head and neck squamous cell carcinomas that is well characterized for relevant clinical parameters, including follow-up.

HbA1c lowering before surgery in poorly controlled diabetes mellitus; a pilot study

to study the feasibility of lowering HbA1c before elective surgery in patients with suboptimalpoorly controlled DM (HbA1c >7%/53 mmol/mol).

'Comparative roentgen stereophotogrammetry analysis of the Taperloc stem with BoneMaster® nano-technology coating compared with cemented and uncemented HA coated Taperloc stem.'

BoneMaster ITo perform a comparative assessment between the clinical, bone remodelling, and radiographic outcomes (as measured with RSA) of the conventional Hydroxyl-Apetite (HA) Taperloc stem compared with Taperloc stem with additional BoneMaster®…

Magnetic Marker Localization for breast cancer surgery: An exploratory study

The purpose of this clinical study is to investigate surgical usability, patient-reported outcomes and effectiveness of the MaMaLoc technique and compare it with WGL.

Lactobacillus casei Shirota for influencing the microbiome of patients with Barrett's esophagus.

Primary objectivesTo study if LcS can colonize the esophagus of BE patients.To study the effect of LcS colonization on the Gr+ (except for LcS)/ Gr- bacterial ratio of the esophagus.Secondary objectivesTo quantify the number of specific pathogenic…

Long-Term Multi-center Evaluation of E-Poly* and Regenerex* Cementless Acetabular Components: Clinical and Radiographic Outcomes

The purposes of this long-term mutli-center study are: - To compare the long-term (10-year) radiographic and clinical outcomes of new E-Poly* liner in primary total hip arthroplasty with the conventional ArcomXL® polyethylene liner.- To compare the…

Prevention of intimal injury during transradial coronary intervention

To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.

Bright light therapy in rheumatoid arthritis to improve symptoms of fatigue and other disease outcomes: a randomized controlled pilot trial.

The primary objective of this pilot trial is to explore the difference between the intervention and control group in change from baseline (T0) to the end of therapy (T1) in therapy efficacy of the primary study outcome fatigue assessed by Checklist…

An explorative study to assess the potential impact of the Incosense Smart in Envida

The aim of this study is to explore the potential impact of the Incosense Smart at the client, professional, care processes and organization.

Target attainment of ciprofloxacin in patients admitted to a general ward: a prospective observational study.

To investigate whether the current dosing regimen of ciprofloxacin, recommended by the Dutch *Stichting Werkgroep Antibioticabeleid* (SWAB) and applied at the Academic Medical Center for patients with various degrees of renal function admitted at…

Observation of oral health and oral microbiome during a 4-month naval mission

The primary objective of this study is to monitor changes in oral health during a 3.5-month naval mission and once one month thereafter.

First attempt success ratio of intravenous cannulation with the Veinplicity®

The primary outcome is the first attempt success ratio of peripheral intravenous catheter placement with the use of the Veinplicity®, when compared to the traditional landmark technique, in patients with a medium-risk profile according to the A-DIVA…

Acute and delayed effects of MDMA intoxication on false memories in a legal context

Primary Objective: to assess the immediate and delayed effects of THC on true and false memories in a legal context (i.e., on eyewitness and offender statements).Secondary Objective(s): to link drug-induced false memory effects to…

Pilot study into the biomechanical working mechanisms of a brace that aims to prevent hip dislocation after total hip replacement surgery

What is the influence of the Rebound Hip and Newport 4 hip brace on restricting the movements that are associated with hip dislocation after at total hip replacement.

Molecular detection of pulmonary oxygen toxicity using exhaled breath analysis after hyperbaric hyperoxic exposure.

Primary Objective: To study the differences between EB post oxygen-dive, post air-dive (control), dry-dive (recompression chamber) and pre-dive (baseline).1. Will an exposure to a PO2 of 190 kPa (100% oxygen at 9 msw) during 60 minutes in an…

Avoiding tacrolimus under- and overexposure by using a new dosing algorithm for pediatric renal transplant recipients

To minimize the occurrence of sub-therapeutic and supra-therapeutic C0 of tacrolimus on day 3, 7 and 10 after transplantation by basing the starting dose of tacrolimus on a dosing algorithm, rather than the standard bodyweight-only-based approach.…

An observational study to determine the pharmacokinetics of pemetrexed with and without hyperhydration during cisplatin administration (HYDRA).

The primary objective is to assess the impact of hyperhydration on pemetrexed pharmacokinetics. The secondary objective is to compare the performance of different renal function algorithms to predict pemetrexed pharmacokinetics.

Closing the preventive care chain for overweight children: evaluation of the implementation of an integrated, locally aligned approach, enforcing primary care.

Get insight in the implementation and effectiveness of the integrated preventive care chain for overweight children in 's-Hertogenbosch. With the results we can optimize the support for overweight children and their parents. .

The impact of milk protein glycation on plasma amino acid responses in healthy young men

To compare the plasma amino acid responses after the digestion of a milk protein powder with varying levels of protein glycation in healthy young men.