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Blind versus Ultrasound-guided Radius Reduction STudy

This multicentre randomised controlled trial aims to investigate whether PoCUS can be used as an adjunct to improve first attempt success rate in closed reductions of displaced distal radial fractures in adults in the ED.

SCOPE for improvement of direct care in early childhood: A Social COmmunication Programme supported by E-health for early identification and intervention of social communication problems possibly associated with autism in primary care

Primary Objective:The main objective of this study is to investigate the effectiveness of BEAR (a parent training combining e-learning and home visits) compared to care-as-usual (CAU) in young children (12-30 months) who are at risk of developing…

Assessing of the microcirculation of the foot, using Laser Speckle Contrast Imaging in patients with end stage PAOD undergoing revascularisation in the Hybrid Operating Theatre

Objective: The primary objective is to analyse whether LSCI could be integrated in a PAOD endovascular operation program in a HOT, for the visualisation of the microcirculation of the foot. Therefore, stability and reproducibility of the system,…

Perturbation-based gait training:
Evaluation of a tool to improve balance and gait in older people at risk of falling.

In this study we want to investigate how a perturbation-based treadmill training with cognitive dual-task improves daily life gait stability in older adults compared to conventional treadmill training with cognitive dual-task.The results of this…

Strong Teens and Resilient Minds: Depression and suicide prevention in secondary vocational education

One of the primary goals is to establish whether students in the first grade of secondary vocational education receiving the multimodal school-based stepped approach towards preventing suicidal behaviours and depression show a clinically significant…

Study: The effect of PSA on the pCO2

In this study we want to show what the consequences are of the respiratory depression that accompanies prolonged PSA

Biomarkers in ALlergic diseases and allergen Immunotherapy

We aim to identify the predictive value of the candidate biomarkers suggested by the EAACI taskforce for response to AIT. Additionally, we aim to explore novel candidate biomarkers both for clinical follow up as well as contribute to unravelling the…

*Trauma-informed approach for unaccompanied refugee minors: a multiple baseline case series*

The primary objective of this study is to measure the effectiveness of the TFT for URMs living in the Netherlands. The research question is as follows: is this TFT effective in decreasing symptoms of posttraumatic stress and depression in URMs…

Quantitative MRI of extra-ocular muscles in myasthenia gravis

1. Explore the diagnostic value by comparing muscle volume, fatty infiltration and oedema/inflammation using qMRI in MG patients, healthy controls and MG mimics (other neuromuscular diseases and Graves* ophthalmopathy (GO) patients).2. Explore the…

Efficacy of online cognitive behavioral therapy on symptoms and quality of life with irritable bowel syndrome.

Primary objective:Is guided online treatment, based on CGT with mindfull- and exposure exercises, with minimal patient contact, effective for IBS-patients as compared to a waiting list?Secondary objectives: Will the guided online treatment lead to…

Gastric emptying and protein absorption of caprine and bovine casein protein

The study aims to quantify differences in gastric digestion and absorption of caprine and bovine casein protein

Can sweeteners encourage the growth of good bacteria? A clinical exploratory pilot study.

To study the effect of sweetener oral rinses on the oral microbiome composition.

Core elements of Cognitive Behavioural Therapy in treatment of depression in youth: does the type and sequence of elements matter

Primary Objective: The primary objective is to establish the differential and sequential effectiveness of cognitive restructuring (CR) and behavioral activation (BA) (and the optimal sequence of these elements) on depressive symptoms (PHQ-2 at post…

DART II. Post-traumatic osteoarthritis of the wrist in elderly patients with displaced intra-articular distal radius fractures. A follow-up study of the DART trial.

Assessing the post traumatic and degenerative radio-carpal osteoarthritis of open reduction and internal fixation compared with non-operative treatment for elderly patients with an intra-articular distal radius fracture.

The effect of audio-visual immersion on pain, anxiety and satisfaction in patients undergoing wrist-fracture reduction in the Emergency Department, a randomized controlled trial

The primary objective of this study is to assess the effect of audio-visual immersion on pain perception in patients undergoing a short surgical procedure (a.i. wrist fracture reduction) under local anesthesia in the Emergency Department (ED).…

Randomized controlled trial to assess the effect of vitamin K supplementation on the rate of elastin degradation in COPD

To evaluate whether supplementation of vitamin K2 decelerates the rate of mature cross-linked elastin degradation inpatients with COPD.

BEWARE 2.0: body awareness training for wearing-off related distress in Parkinson's disease patients

Do patients that receive the BEWARE training have a higher score on the Chronic Illness Acceptance Questionnaire at the end of treatment (and at 3 month follow-up) compared to the treatment as usual (physical therapy only)?

Neonatal outcome after cardiovascular remodelling in fetal growth restriction

To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.

Difference in Patient Reported Outcomes at 1 year after 6 or 8 weeks of carpometacarpal joint distraction: a Randomized Controlled Non-Inferiority Trial.

Primary Hypothesis: - There is a difference in PROMIS Physical Function Upper Extremity Short Form (PROMIS PF UE SF) score between group A (6 weeks distraction) and group B (8 weeks distraction) at 1 year after first carpometacarpal joint…

Use of upper airway measurements for the prediction of successful mandibular advancement device therapy both in protrusion and retraction of the mandible in patients with obstructive sleep apnoea.

The aim of this study is to investigate the use of spirometry, forced oscillation technique (FOT), and negative expiratory pressure (NEP) in both protrusion and retraction of the mandible as prediction measurements for MAD success.