The study aims to quantify differences in gastric digestion and absorption of caprine and bovine casein protein
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
gezonde deelnemers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
gastric emptying t50
amino acids concentration over time in the blood
Secondary outcome
intragastric layering over time
Background summary
A suggested benefit of caprine (CAP) over bovine milk (BOV) has been
hypothesized to be an accelerated gastric emptying of CAP. Due to more *-casein
and less *s1-casein in caprine milk less coarse coagulates are thought to be
formed in the stomach, which may facilitate enzymatic digestion and gastric
emptying.
This may provide benefits for specific groups, for example patients who
struggle to meet protein intakes as protein. However, thus far, no in vivo
clinical data on digestion of caprine versus bovine casein is available.
Study objective
The study aims to quantify differences in gastric digestion and absorption of
caprine and bovine casein protein
Study design
Intervention study with a balanced cross-over design
Intervention
300mL vanilla flavoured drink with either 30r of caprine casein of bovine
casein
Study burden and risks
The risks associated with participation are negligible, as both phlebotomy and
MRI are eminently safe medical techniques, and the stimuli consist of normally
consumed food products. The burden associated with participation consists of
two visits, which both require an overnight fast, 8 blood draws (10 mL per
draw, totalling 80 mL) and multiple MRI scans over the period of 1 hours. These
may all cause minimal discomfort. These is no benefit to participation for the
participants, the group is only related insofar as they are healthy males.
stippeneng 4
Wageningen 6708WE
NL
stippeneng 4
Wageningen 6708WE
NL
Listed location countries
Age
Inclusion criteria
* Male
* 18 - 55 yr old
* In self-reported health
* BMI between 18 and 25kg/m2
Exclusion criteria
* Bovine milk allergy or intolerance (self-reported)
* Caprine milk allergy or intolerance (self-reported)
* Lactose intolerance (self-reported)
* Disorders of the upper ingestive tract resulting in difficulties
chewing/swallowing.
* Unexplained weight change
* Gastric disorders or regular gastric complaints, heart burn for example
* Use of proton pump inhibitors or other medication which alters the normal
function-ing of the stomach
* Smoking
* Having a contra-indication to MRI scanning (including, but not limited to):
* Pacemakers and defibrillators
* Intraorbital or intraocular metallic fragments
* Ferromagnetic implants
* Claustrofobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL70239.081.19 |
| Other | nog geen nummer toegewezen |
| OMON | NL-OMON28580 |