The study aims to quantify differences in gastric digestion and absorption of caprine and bovine casein protein
ID
Source
Brief title
Condition
- Protein and amino acid metabolism disorders NEC
Synonym
Health condition
'gastric emptying' and 'amino acid absorption'
Research involving
Sponsors and support
Intervention
- Food (substances)
Outcome measures
Primary outcome
Gastric emptying and amino acid absorption
Secondary outcome
Intragastric layer formation
Background summary
This may provide benefits for specific groups, for example patients who struggle to meet protein intakes as protein. However, thus far, no in vivo clinical data on digestion of caprine versus bovine casein is available.
Study objective
Study design
Intervention
Study burden and risks
| The risks associated with participation are negligible, as both phlebotomy and MRI are eminently safe medical techniques, and the stimuli consist of normally consumed food products. The burden associated with participation consists of two visits, which both require an overnight fast, 8 blood draws (10 mL per draw, totalling 80 mL) and multiple MRI scans over the period of 1 hours. These may all cause minimal discomfort. These is no benefit to participation for the participants, the group is only related insofar as they are healthy males. |
Age
Inclusion criteria
• Male • 18 - 55 yr old • In self-reported health • BMI between 18 and 25 kg/m2
Exclusion criteria
• Bovine milk allergy or intolerance (self-reported) • Caprine milk allergy or intolerance (self-reported) • Lactose intolerance (self-reported) • Gastric disorders or regular gastric complaints, heart burn for example • Use of proton pump inhibitors or other medication which alters the normal function-ing of the stomach • Being vegan • Participating in other research • Smoking • Having a contra-indication to MRI scanning (including, but not limited to): Pacemakers and defibrillators Intraorbital or intraocular metallic fragments Ferromagnetic implants Claustrofobia
Design
Recruitment
IPD sharing statement
p/a Radboudumc, huispost 628,
Postbus 9101
6500 HB Nijmegen
024 361 3154
commissiemensgebondenonderzoek@radboudumc.nl
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8137 |
| Other | METC Wageningen : 70239 |
| CCMO | NL70239.081.19 |
| OMON | NL-OMON48463 |