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The role of the pulmonary vasculature in the Fontan circulation

Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…

Epithelial barrier in obesity

The aim of this study is to assess differences between lean and morbidly obese subjects in gut permeability, gut microbiota and mucosal inflammation and to assess the effects of weight loss after sleeve gastrectomy on gut permeability, microbiota…

Detection of thyrotrophin receptor and contractility in human myometrium

Immunodetection of Thyrothrophin (TSH) receptor in myometrium tissue.Furtermore the aim is to test myometrium tissue in vitro for it's relaxation and contractility and it's conductance of electropotentials.

The role of innate immunity in the pathogenesis of acute respiratory syncytial virus lower respiratory tract infection:
Repeated measurements of nasopharyngeal type 1 interferon levels in RSV infections

To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…

Tilburg Health Outcomes Registry of Emotional Stress in Coronary Intervention (THORESCI)

(1) To examine the adherence to the prevention and PCI guidelines and the effects thereof on long term prognosis in PCI patients. (2) To evaluate the effectiveness of the psychosocial screening instrument of the European Society of Cardiology…

Muscle endurance of the upper and lower extremity

- Examine the reproducibility of the non-volitional endurance test in healthy subjects. The hypothesis is that the non-volitional endurance test is reproducible.- Comparing arm and leg muscle endurance in healthy subjects. It is expected that arm…

Development of (moderately) preterm infants: regulation skills, parent-infant interaction and parental emotions.

The main question in the study isHow do moderately preterm infants and their parents differ from term, as well as extreme preterm infants in (a) development and self regulation skills of the infants, (b) interaction patterns and relationship between…

Differences in inflammatory and hemostatic response in cardiac surgery patients operated with conventional Cardiopulmonary Bypass (CPB) versus Minimized Extracorporeal Circulation (MECC).

The primary objective of this study is to define differences in the inflammatory response, coagulation, and fibrinolysis in CABG patients with either MECC or conventional CPB.

Effect of salsalate on lipid induced insulin resistance

Using the model of lipid-induced insulin resistance we will study the hypothesis that pre-treatment with salsalate (salicylsalicylic acid) blunts the development of lipid-induced insulin resistant in an I*B/NF*B dependent manner in healthy human…

Urethral support after CS in women with breech presentation at term

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Left Bundle Branch Block after Transcatheter Aortic Valve Implantation (TAVI)

1. to compare the extent of reversal of left ventricular remodelling at 3 months and 1 year after a TAVI procedure between patients with a TAVI-induced LBBB and patients without a LBBB; 2. comparison of strain patterns in TAVI-induced LBBB (as being…

Paradoxical and venous Gas Embolism During Hysteroscopic Surgery Detected by Trans Esophageal Echocardiography: A comparison using either bipolar or monopolar diathermia

To determine the incidence and grade of venous emboli and/or paradoxical gas emboli during hysteroscopy surgery using TOE. In addition, a comparison will be made using either bipolar or monopolar diathermia. Knowing the incidence and severity of…

Quantitative and qualitative determination of natural occuring regulatory t cells in blood and bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis and healthy volunteers.

The primary goal of this research is to characterize the regulatory Treg population in peripheral blood and bronchoalveolar lavage in patients with sarcoidosis compared to healthy controls. What is the frequency of these cells, what is the phenetype…

Differences in tissue and plasma PYY and GLP-1 in lean and obese human subjects

Primary Objective: To assess the differences between lean and obese subjects in tissue PYY and GLP-1 levels and gene activity, and in L-cellular secretion before and directly after nutrient exposure. Secondary Objective: To correlate these…

Determination of risk factors for developing osteoporosis in COPD GOLD II patients. A case control study to identify possible risk factors for developing osteoporosis in COPD GOLD II patients.

Determination of possible risk factors for developing osteoporosis in GOLD II COPD patients.

Insertion of a central venous catheter through a tegaderm as a preventive measure against catheter colonization and infection

Primary: Investigate if sterile transparent dressing pasted on the skin before CVC insertion reduces the contamination risk of the CVC.Secondary: Investigate if direct contamination has a clinical significance.Investigate what the mayor…

The influence of fetal seks on the maternal immunity

The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…

A symptom-based examination of possible electrophysiological measures of Autism Spectrum Disorder (ASD).

Using electroencephalography to relate behavioural research on Autism Spectrum Disorder (ASD) to electrophysiological findings.

Interactions between tumor cells and lymphocytes in classical Hodgkin lymphoma

To study the interaction between normal T lymphocytes and Hodgkin tumor cells in an in vitro model.

GE-ID study
Gastro-intestinal Expression profiles in Immune-mediated Diseases study. An explorative study for tissue specific patterns in inflammatory diseases of the gastrointestinal tract

Objective: As we have to integrate information on genetics, immune cells and microbes, a panel of biomaterials (isolated from blood, stool and gastrointestinal mucosal biopsies) will be sampled. From these samples genomic, transcriptomic,…