20 results
1º Is there a significant difference of more than 10% in the pharmacokinetic parameter AUC of the investigated antineoplastic drugs (as a surrogate parameter for the efficacy) in the presence and absence of NNRTIs and/or PIs?2º Are there clinically…
There's alack of randomized controlled trials for the treatment of primary squamous cell carcinoma of the skin and randomized comparative studies are recommended. With this pilot study, we want to study the effectiveness of Mohs'…
Our primary objective is to assess the absence of binary restenosis rate, the reocclusion rate and target-lesion revascularization rate of endovascular treatment of advanced atherosclerotic lesions of the common iliac artery with a balloon…
Better knowledge and awareness of Late Effects after pediatric HSCT for non-malignant diseases will lead to optimal screening procedures after HSCT that may eventually contribute to reduce transplant-related long term morbidity and mortality and…
To further research nintedanib PK and correlate them with clinical parameters and toxicity. Results could be used to optimize treatment of nintedanib in the future by dose individualization based on patient*s characteristics or therapeutic drug…
To determine if re-irradiation in 4 fractions is non-inferior to 10 fractions in the primary endpoint of survival after re-irradiation. Secondary objectives are to establish and compare health related quality of life (HRQoL), recurrence patterns,…
The primary objective of this study is to validate the *Hearing and Sound* questionnaire, developed by *VeiligheidNL*, which addresses exposure to noise through headphone use and visiting events with amplified music. The main study endpoint is to…
The main objective of this project is to identify the early brain changes in MS (i.e. patients that are recently diagnosed with MS) that can be measured by advanced structural and functional (network) imaging measures. Additionally, we will…
Primary objectives: • To define any alterations in the oral and gut microbiome and metabolome in patients with HNSCC compared to healthy controls;• To investigate the dynamics oral and gut microbiome and metabolome in HNSCC before, during and after…
Primary Objective: to evaluate arterial [18F]fluor-PEG-folate uptake on PET/CT in patients with active, large vessel GCA; and in the same patients after 9 months of standard treatment.Secondary objectives are:- Assessment of the relationship between…
The aim of this study is to explore differences in expression of Rac1 and pSTAT3 in leucocytes of therapy-naïve IBD patients, IBD patients on immune suppressive therapy and healthy controls.
In this study we want to investigate if there is a difference in exposure to losartan and perindopril between younger and elderly patients. Furthermore, the results will enable us to correlate detailed PK data with PD data, which can lead to a more…
Primary objective:Does the use of the application support a positive lifestyle development?Secondary objectives:Does the use of the application support an increase in physical activity levels?Does the use of the application has a positive influence…
To assess the inter- and intra-variability of MCA PI, UA PI, UtA PI and CPR between 32 and 40 weeks of gestation.
To investigate the non-inferiority of a reduced dose and to develop biomarkers for early treatment response.
To investigate visual function recovery after surgery for foveal splitting RRD.
The goal of this study is to demonstrate the value of SAVI (both non-invasive and invasive) in patients with moderate aortic stenosis. The short-term objective will compare SAVI with standard resting indexes for symptom burden, functional capacity,…
• To demonstrate the clinical utility of POCS in cadaveric donor or live donor liver transplantation patients referred for endoscopic retrograde cholangiopancreatography (ERCP) in the setting of a clinical suspicion of post-liver transplant bile…
The purposes of the study are to evaluate the following measures and, as applicable, compare them to the comparator group results:1. Determine if physical measurements and PROMs are similar between groups2. Determine if subject satisfaction is…
LANDMARK Trial is designed to compare safety and effectiveness of Meril*s Myval Transcatheter Heart Valve (THV) series vs. Contemporary Valves (Edwards* Sapien THV series and Medtronic*s Evolut THV series) in patients with severe symptomatic native…