To assess the inter- and intra-variability of MCA PI, UA PI, UtA PI and CPR between 32 and 40 weeks of gestation.
ID
Source
Brief title
Condition
- Pregnancy, labour, delivery and postpartum conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Inter- and intra-observer reproducibility of the MCA, UA, UtA pulsatility
indices (PI) and the CPR.
Secondary outcome
Correlation between gestational age and the inter- and intra-variability of
pulsatility indices (PI) of the MCA, UA, UtA and the CPR.
Background summary
Doppler ultrasound measurements are increasingly performed in clinical practice
to detect signs of fetal compromise and distinguish the healthy fetus from the
fetus at risk. These include the measurements of the pulsatility indices (PI)
of umbilical artery (UA) and the middle cerebral artery (MCA), as well as the
Cerebro Placental Ratio (CPR - which is calculated by dividing the MCA PI by
the UA PI). A low CPR - a sign of brainsparing - is indicative of placental
insufficiency and a marker of adverse pregnancy outcomes. Although currently
only used in clinical practice in the first en second trimester, the Doppler of
the uterine artery (UtA) is also gaining more and more attention as a third
trimester marker for placental function
However, the test characteristics have not been adequately studied yet.
Study objective
To assess the inter- and intra-variability of MCA PI, UA PI, UtA PI and CPR
between 32 and 40 weeks of gestation.
Study design
Prospective observational study.
Study burden and risks
Additional ultrasound measurements are performed just after the visit at the
outpatient clinic. No extra hospital visit is required. These additional
measurements take about 30 minutes. There are no risks or benefits associated
with participation.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
Singleton pregnancies between 32 and 40 weeks of gestation.
Exclusion criteria
- Maternal age <18 years
- Inability to give informed consent
- Chromosomal abnormalities or major congenital malformations (including SUA).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL73766.018.20 |