We hypothesize that the inter-observer variability of the CPR, MCA, UA and UtA measurement will be less than intra-observer variability due to normal biological variation of cardiovascular control.
ID
Source
Brief title
Condition
- Pregnancy, labour, delivery and postpartum conditions
Health condition
Pregnancy
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Inter- and intra-observer variability in Doppler ultrasound measurement of MCA, UA, UtA, CPR.
Secondary outcome
Secondary outcome includes the correlation between gestational age and inter- and intra-variability of the Doppler ultrasound measurements of the MCA, UA, UtA and the CPR.
Background summary
Doppler ultrasound measurements are increasingly performed in clinical practice to detect signs of fetal compromise and distinguish the healthy fetus from the fetus at risk. These include the measurements of the pulsatility indices (PI) of the umbilical artery (UA) and the middle cerebral artery (MCA), as well as the Cerebro Placental Ratio (CPR – which is calculated by dividing the MCA PI by the UA PI). A low CPR is indicative of placental insufficiency and a marker of adverse outcomes. Although currently only used in clinical practice in the first en second trimester, the Doppler of the uterine artery (UtA) is also gaining more and more attention as a third trimester marker for placental function. However, the test characteristics of these Doppler measurements in the third trimester of pregnancy have not been adequately studied yet. The aim of this study is to assess the inter- and intra-observer variability of Doppler ultrasound measurements in fetuses between 32 and 40 weeks of gestation, including the MCA, UA, UtA and CPR.
Study objective
We hypothesize that the inter-observer variability of the CPR, MCA, UA and UtA measurement will be less than intra-observer variability due to normal biological variation of cardiovascular control.
Study design
Primary outcome will be analysed after data completion of the 40 subjects. No follow up takes place.
Intervention
Not applicable
Age
Inclusion criteria
Singleton pregnancies with gestational age between 32+0 and 40+0 weeks.
Exclusion criteria
- Maternal age <18 years - Inability to give informed consent - Multiple pregnancy - Abnormal fetal heart tracings - Major congenital malformations (including single umbilical artery) or chromosomal abnormalities
Design
Recruitment
IPD sharing statement
Kamer G4-214
Postbus 22660
1100 DD Amsterdam
020 566 7389
mecamc@amsterdamumc.nl
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8988 |
| CCMO | NL73766.018.20 |
| OMON | NL-OMON49138 |