23 results
(1) To examine the adherence to the prevention and PCI guidelines and the effects thereof on long term prognosis in PCI patients. (2) To evaluate the effectiveness of the psychosocial screening instrument of the European Society of Cardiology…
To assess toxicity of MRI guided focal salvage high-dose-rate brachytherapy as monotherapy in patients with locally recurrent prostate cancer. As secondary objectives, technical feasibility, quality of life and biochemical free survival (Phoenix…
1) Assess the whole genome sequence (WGS) and clinical profile of the MPX families to identify how rare and common genetic variants interact to produce shared versus distinct NDDs and clinical features in individuals, or different combinations of…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
Primary Objective:- To investigate the association between temporal evolutions of blood biomarkers and clinical adverse events, in order to produce a dynamic, individual, and accurate prediction model for patients with HFpEFSecondary Objective(s):-…
The primary objectives of the pilot study are: 1. To determine a successful strategy for recruiting and following-up participants during their transition phase from home to a nursing home; 2. To determine the suitability of the study procedure; 3.…
Primary Objective: 1. To evaluate the ablation lesion characteristics of different ablation modalities and strategies Secondary Objectives: 2. To evaluate the ablation lesion characteristics of different ablation energy profiles; 3. To evaluate the…
The primary objective is to compare the IntelLeg Knee on the execution of a subset of daily activities for individuals with a transfemoral amputation to auto-adaptive or mechanical (non-powered) prosthetic knee via musculoskeletal simulation. The…
Primary Objective: The primary outcome of this study is successful implementation of home-based blood sampling. The success criteria is that 25% or more of the blood assessments are actually performed at home by the patients themselves using a self-…
With this study we aim to prove that personalized B cell tailored ocrelizumab treatment is non-inferior in the suppression of MS disease activity (clinically and radiologically) compared to the standard (fixed 24 week interval) treatment.
DOSE ESCALATION PHASE: PART A: Primary Objectives: • To assess the safety and tolerability of KBA1412 when given as monotherapy. • To determine the maximum tolerated dose (MTD) and/or Recommended Phase II dose (RP2D) of KBA1412 when given as…
The aim of this study is to get more insight in the pathogenesis of (P)SCR by comparing: (1) Red cell characteristics (deformability and point of sickling in hypoxia measured by the Oxygenscan), (2) Angiogenesis by determining several biomarkers of…
For this reason, we will conduct an intervention study aimed at promoting the health of (future) parents. The concrete goal of this intervention is to improve the health of (future) parents by optimizing lifestyle in the preconception period and…
Primary Objectives: 1. To assess the metabolic profile of patients with Dravet syndrome and identify metabolic variations that contribute to the pathophysiology of seizures and developmental delaySecondary Objectives:2. To assess the association…
The primary objective of the study is to assess the pharmacokinetics (PK) of PXL770 in AMN subjects at the dose of 500mg once daily (OD) and 250mg twice daily (BID) after 4 weeks of treatment.
The primary objective of this trial is to assess the effects of WHM, involving breathing exercises, mindset (and cold exposure), on health-related quality of life in people with SCI. The secondary objectives are to assess the effects of WHM,…
Improving the clinical effect and efficiency of DBS for PD by investigating patient specific patterns of neuronal cell activity in the brain that are associated with symptom-severity. This may improve the clinical effect of DBS, and also result in…
Therefore, this feasibility study will evaluate whether the 18F-PSMA PET/CT is capable of MTC lesion detection. Moreover, we will compare its ability to detect MTC lesions with a routinely used PET scan, the 18F-FDG PET. By exploring new tracers in…
The objective of this study is to detect whether stimulation during task induced activation of brainnetworks leads to a higher efficacy of rTMS and other neurobiological changes.
To assess the predictive value of early response measurements on PSMA-PET/CT for therapy success, defined as time to development of castration-resistant prostate cancer (CRPC), in order to personalize treatment choice.