29 results
There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.
At CHDR, experience has been gained with the assessment of the in vitro inhibition by MAP kinases of the LPS-induced TNFα release in healthy male volunteers. However, relatively little is known on the inhibition by MAP-kinases in other populations.…
We will perform a study to describe the echogenicity of the substantia nigra, red nucleus and brainstem raphe in PD patients with and without RLS, RLS patients without PD and healthy controls. The echogenicity will be correlated with the the serum…
1) Compare a group of bilateral users to a unilateral control group (between-subject design)2) Compare unilateral use to bilateral use after sequential implantation (within-subject design)3) Compare simultaneous bilateral implantation to sequential…
The aim of the Anti-Interleukin-1 in Diabetes Action trial (AIDA) study is to test the feasibility, safety/tolerability and potential efficacy of anti-IL-1 therapy in maintaining or enhancing beta-cell function in people with new-onset Type 1…
Do pre-processed bone chips have lower contamination rates compared to femoral heads, morselised at the operating theatre measured at different moments during hip revision arthroplasty?
This project aims at evaluating the reliability, validity, and the practical relevance of the SDQ Self Report compared to KIVPA (a Dutch questionnaire to detect psychosocial problems in adolescents). The study findings may support the Dutch policy…
Investigate the CGMS results in comparison with an OGTT and one-day self monitoring of blood glucose. Thereby compare the glucose patterns of patients with an impaired glucose tolerance to patient with a normal glucose tolerance and CFRD.
This project aims at evaluating the reliability, validity, and the added value of the SDQ (Parent Format ) compared to LSPPK (a Dutch questionnaire to detect psychosocial problems in toddlers and children). The study findings may support the Dutch…
Aim of the project is to determine whether it is possible to implement a CAT for the identification of children with psychosocial problems in Dutch JGZ. Additionally the study will evaluate the CAT as it is being used in practice. The trial…
1. Characterization of patients with persistent and recurrent primary hyperparathyroidism after at least one parathyroidectomy, with removal of at least one pathological parathyroid gland.2. Evaluation of pre-operative localization studies;…
The use of Motivational Interviewing to promote physical activity in patients with RA: a pilot study
To make an inventory of whether:• Physical therapists who had a training on MI apply more MI technics and selfregulation principles during advising of physical inactive patients with RA that physical therapists who did not have a MI training? • An…
We hypothesize that the new MRI protocol will be sensitive enough to detect a diagnostic change of >= 50% change from the normal shaped trachea. The primary objective of this study is to determine sensitivity, and specificity, of our MRI…
To evaluate the safety and performance of the MobiusHD system in subjects with resistant hypertension. Substudy HF:As above, and obtain an initial understanding of the efficacy of the MobiusHD System on cardiac performance and functional status in…
The primary objective is to determine whether adjuvant treatment with natural dendritic cell (nDC) vaccination, after complete radical lymph node dissection or sentinel node procedure in stage IIIB and IIIC melanoma patients, improves recurrence-…
The proposed study aims to examine the antidepressant efficacy of oral S-ketamine augmentation in patients with TRD treated with regular antidepressants in a double-blind randomised controlled trial. Secondary questions involve the effects of oral S…
Primary Objective: to investigate whether half-dose PDT treatment leads to a higher percentage of cCSC patients with SRF on OCT at baseline, achieving an absence of this SRF on OCT as compared to eplerenone treatment.Secondary Objectives: to…
To evaluate whether YCF with added scGOS/lcFOS and n-3 LCPFUAs can decrease the number of upper respiratory tract infections compared to cow*s milk in children aged 12-36 months with recurrent upper respiratory tract infections.