16 results
There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…
To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
We hypothesize that the new MRI protocol will be sensitive enough to detect a diagnostic change of >= 50% change from the normal shaped trachea. The primary objective of this study is to determine sensitivity, and specificity, of our MRI…
Primary Objective: To optimize the current DBS-treatment of advanced PD. For the primary objective the following research questions will be answered: By performing STN DBS under general anesthesia, will there be a significant reduction in cognitive…
To evaluate whether YCF with added scGOS/lcFOS and n-3 LCPFUAs can decrease the number of upper respiratory tract infections compared to cow*s milk in children aged 12-36 months with recurrent upper respiratory tract infections.
The primary objective is to determine whether adjuvant treatment with natural dendritic cell (nDC) vaccination, after complete radical lymph node dissection or sentinel node procedure in stage IIIB and IIIC melanoma patients, improves recurrence-…
The proposed study aims to examine the antidepressant efficacy of oral S-ketamine augmentation in patients with TRD treated with regular antidepressants in a double-blind randomised controlled trial. Secondary questions involve the effects of oral S…
To evaluate the safety and performance of the MobiusHD system in subjects with resistant hypertension. Substudy HF:As above, and obtain an initial understanding of the efficacy of the MobiusHD System on cardiac performance and functional status in…
• AIS is a chronic condition of the back. Once the curvature shows progression and exceeds a Cobb angle of about 20 degrees, chances are small that this curvature will disappear spontaneously.2 There is little epidemiological data of the Netherlands…
Primary Objective: to investigate whether half-dose PDT treatment leads to a higher percentage of cCSC patients with SRF on OCT at baseline, achieving an absence of this SRF on OCT as compared to eplerenone treatment.Secondary Objectives: to…
The primary objective of this study is to:• Determine the safety and tolerability of AG-120 and AG-221 when administered with induction and consolidation therapy in patients with newly diagnosed acute myeloid leukemia (AML) with an isocitrate…
The main focus of the present proposal is a first step towards treatment intensity de-escalation in older breast cancer patients. For this, we propose to initiate the first TOP consortium study (TOP-1) that will study the effect of omitting…
Primary ObjectiveThis proposal concerns the inclusion of a peripheral quantitative computed tomography (pQCT) device in the Rotterdam Study to perform osteoporosis etiological research. Since 1990, the Rotterdam Study has performed research in the…
To collect long term outcomes on the use of the Neovasc Reducer
to assess general sexual functioning, genital sexual responsiveness, subjective sexual responsiveness and affect in women with PCOS , and to make a comparison of these results with the results of an age matched healthy control group of women.…