Search for a trial

Improving ADL nursing care of long-term care clients

Care workers and clients allocated to the intervention arm (receiving access to the ZELF program) will improve their 'stimulation behavior' and 'optimize function' respectively.

Impact of A2 milk versus conventional milk on intestinal health: a proof-of-concept study in Irritable Bowel Syndrome patients

This study will be done to gain insights in the effects of A2 milk on GI symptoms, and immune and defense parameters, in IBS patients. The information will gain more insights in the working mechanism of different types of beta-casein in individuals…

Nonsimultaneous Rapid Pulse Trains (RaPiT) with Current Steering for Loudness Integration as a Basis for a new Loudness Encoding Strategy in Cochlear Implant Subjects

1.To assess if multiple sequentially steered pulses can reach appropriate loudness while main-taining a single percept in cochlear implant subjects2.To compare loudness growth of sequentially steered pulse trains with those of conventional monopolar…

Hypnotherapy through self-exercises in children with functional abdominal pain
in primary care

To determine the (cost)-effectiveness of home-based hypnotherapy by self-exercises added to usual care (UC) of general practitioners (GPs) compared with UC of GPs alone in children with FAP or IBS.

Sweet tooth: Nature or Nurture? Role of long-term dietary sweetness exposure on sweetness preferences

To assess the effect of a 6-month regular, low and high dietary sweetness exposure on sweetness preferences, food intake, glucose homeostasis and body weight in healthy adults.

Real-life and challenging gait skills to evaluate performance after cruciate-retaining total knee arthroplasy

1) To compare gait quality in daily life and challenging gait skills of patients 1 year following cruciate-retaining TKA compared to a healthy, age and gender matched cohort.2) To compare pre- to post-operative cruciate TKA status in quantity and…

Assessment of exercise induced respiratory symptoms in children using electromyography

To determine the differences in muscular activity of the diaphragm between children with controlled asthma, uncontrolled asthma, dysfunctional breathing patterns and healthy children.

Determination of the iodine status in pregnant women in the Netherlands.
Are current iodine intake recommendations still adequate?

To determine iodine deficiency in pregnant women in the Netherlands.

Interferon gamma release assays for Q fever: Evaluation of new test formats in exposure screening to C. burnetii

The objective of the current study is to evaluate the performance of two new formats of the IGRA using pre-filled antigen formulations in a cohort of Dutch individuals with known prior exposure to Cb.

Effectiveness of customized corneal crosslinking versus standard corneal crosslinking in patients with progressive keratoconus

The objective of this project is to evaluate whether the effectiveness of customized cross-linking (cCXL) is non-inferior to the standard cross-linking protocol (sCXL).

A Multicenter Clinical Validation Study of EsoGuard® on Samples Collected Using EsoCheck® for the Detection of Barrett*s Esophagus with and without Dysplasia, and/or Esophageal Adenocarcinoma, using Esophagogastroduodenoscopy as the Diagnostic Comparator

The overall objective for this study is to train and validate EsoGuard-based diagnosis characteristics

Wishing to decrease Aquaresis in ADPKD patients Treated with a V2Ra; the Effect of Regulating protein and salt

To demonstrate the effect of salt and/or protein intake on aquaresis in patients with ADPKD who are treated with a vasopressin V2 receptor antagonist as measured by 24-hour urine volume.

Optimizing nutritional counseling for the disabled athlete

This project aims to assess whether the nutritional intake of Paralympic athletes meets their physiological demands. Therefore, we will investigate energy expenditure, dietary intake, body composition and bone health of disabled athletes, ultimately…

Progesterone for Breast Development in Trans Women; Assessment of effects and safety -a pilot trial-

To explore the effects on breast development of addition of progesterone to the treatment with estradiol in trans women after vaginoplasty or orchiectomy. Secondary objectives include safety and patient satisfaction, mood, and sleep.

Longitudinal European Autism Project (LEAP). Follow-up-2 (wave-3)

1. To identify biomarkers and methodologies (neuroimaging, eye tracking, cognition, biochemistry, proteomics, genomics, etc.) that can be used to stratify patient groups into more homogeneous subgroups and/or that predict clinical outcome of…

Outcome and cost-effectiveness of a dynamic Lucerne-cast versus a static forearm-cast in patients with fractures (shaft, intra-articular, sub-capital) of the metacarpal bone, requiring non-operative treatment

Ninety percent of Metacarpal fractures (MCFs) (neck, shaft and intra-articular fractures) are treated non-operatively. Generally, non-operative treatment is defined as immobilization by a forearm cast. Recently it was shown that patients with 5th…

Ciprofloxacin pharmacokinetics after IV and oral administration in cachectic elderly patients

Primary Objective: - To study the pharmacokinetics (CL, Vd, and F) of ciprofloxacin in cachectic elderly patients and compare with normal weight participants.Secondary Objective(s): - To assess the influence of covariates (such as TBW, LBW, serum…

Continuous and Bi-level positive airway pressure for motion mitigation of intra-thoracic tumors treated with radiotherapy

The main objective of this pilot study is to evaluate the effect of motion mitigation with BiPAP or CPAP on tumor motion during the course of radiotherapy in patients with intra-thoracic tumors.

Exercise Enhances: A randomized controlled trial on aerobic exercise as depression treatment augmentation strategy

Is care as usual (CAU) with adjunct evidence-based prescription of exercise more effective than CAU alone in reducingdepressive symptoms in patients with major depressive disorder in the specialised mental health service setting?

K-wire fixation with direct moBilization versus Open Reposition anD intErnal fixation with direct mobilizAtion in Unstable proXimal phalangeal shaft fractures.

To assess the functional outcomes and cost-effectiveness of K-wire fixation followed by direct mobilization versus open reposition and internal fixation with direct mobilization in adult patients with unstable shaft fractures and fractures with a…