31 results
Primary Objective: The treatment result expressed as the proportion of successful treatments per treatment arm (successful = VUR <= grade 1 and/or no urinary-tract infections 6 months after the operation) does at least not show a significant…
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…
The first objective of this study is to gain insight in which neurocognitive and neurobiological processes underlie the development of externalizing behavior (in specific aggressive behavior) in the first two years of life. The second objective is…
The aim of this study is to examine the daily level of activities and participation after LTH in children and adolescents (6-18 years) and to identify possible predictors. In addition, experimental research is done in a subgroup to measure the…
To establish the incidence and consequences (impairments op body functions, limitations in participation) of traumatic brain injury in children and youth in a region of The Netherlands as well as the incidence of the same symptoms in a group of…
We aim to answer the following research questions:What is the prevalence of child maltreatment in the Netherlands?Which types of maltreatment are prevalent and how are they interrelated?What are characteristics of the victims of child maltreatment?…
a. analysis of the usefulness of new molecular biological techniques in the diagnostic process of short stature, especially the detection of small chromosomal anomalies.b. identification of genetic factors causing short stature or influencing the…
We propose an instrumented approach, during which the ankle is rotated in a precise and controlled way using a robot manipulator. Using neuromuscular modelling, key neuromechanical parameters as viscosity, stiffness and reflexive torque can be…
We propose that variation in genes involved in the regulation of motivational behaviour and satiety plays a major role in the development of obesity. We aim to identify these genes using family-based association and linkage analysis in a large…
The main objective is to assess the causational factors (genetic factors within r(X) or the marker chromosomes, genetic factors within the other X chromosome and genetic factors within the autosomes) in the development of mental retardation,…
This project aims at evaluating the reliability, validity, and the practical relevance of the SDQ Self Report compared to KIVPA (a Dutch questionnaire to detect psychosocial problems in adolescents). The study findings may support the Dutch policy…
We hypothesize that the new MRI protocol will be sensitive enough to detect a diagnostic change of >= 50% change from the normal shaped trachea. The primary objective of this study is to determine sensitivity, and specificity, of our MRI…
The primary objective is to evaluate the efficacy of avacopan compared to placebo based on histologic changes in kidney biopsies taken before and during treatment.The secondary objectives of this study include evaluation of:1. The safety of avacopan…
With this study we try to answer the following question:What is the clinical outcome after a corrective osteotomy of a forearm malunion when we virtually plan the correction preoperatively and whether or not use patient-specific guides…
To determine the (cost)-effectiveness of home-based hypnotherapy by self-exercises added to usual care (UC) of general practitioners (GPs) compared with UC of GPs alone in children with FAP or IBS.
To determine the differences in muscular activity of the diaphragm between children with controlled asthma, uncontrolled asthma, dysfunctional breathing patterns and healthy children.
Primary research questions:(1) What is the rate of persistent DSM-5 moderate to severe SUD from adolescence to young adulthood among youth in addiction treatment?(2) What is the prognostic value of a general population-based set of predictors of…
Primary objective:1. To study the relation between muscle FF and two major clinical endpoints in different phases of the disease in non-ambulant DMD patients. Secondary objectives:2. To explore the use of Microsoft Kinect and Leap Motion in relation…
This project aims to assess whether the nutritional intake of Paralympic athletes meets their physiological demands. Therefore, we will investigate energy expenditure, dietary intake, body composition and bone health of disabled athletes, ultimately…