30 results
To assess whether preoperative radiotherapy, as an adjunct to curative-intent surgery, improves the abdominal local recurrence-free survival.
The goal of this study is to better characterize the metabolic alterations and sugar structure alterations (glycosylation abnormalities) in patients diagnosed with Congenital Disorders of Glycosylation.
Primary ObjectiveThe primary objective of this study will be to compare the efficacy of infliximab with that of placebo in the prevention of clinical recurrence of CD through Week 76, defined as a composite endpoint that requires endoscopic…
To compare the effects on the APC- (Activated Protein C) resistance ratio (ETP-[endogenous throbin potential] based) between the pivotal phase III NOMAC-E2 batch and a commercial NOMAC-E2 batchTo compare the effects on all other metabolic parameters…
Demonstrate superiority of NEVANAC® (nepafenac ophthalmic suspension) 0.1% relative to nepafenac vehicle based on the percentage of diabetic retinopathy patients who develop macular edema (defined as >=30% increase from pre-operative baseline…
To evaluate the efficacy of ROLL versus WGL in breast conserving surgery for non-palpable breast cancer.
The central hypothesis of this project is that atorvastatin (added on standard antihypertensive treatment ARB) causes a substantial decrease in MSNA in hypertensive patients with CKD.
The objective of this study is to validate a newly designed self-help treatment for nightmares. This self-help treatment is based on Imagery Rehearsal Therapy. This treatment will be validated in comparison to an exposure treatment a diary condition…
To compare the palliative efficacy of talc pleurodesis with the indwelling catheter
Primary Objective: The primary objective is to investigate the feasibility of a short-term preoperative physical therapeutic intervention for frail elderly patients, who have a higher risk on postoperative complications or a delayed recovery, after…
zie study protocol
The primary efficacy variable is if the TachoSil application was feasible. A feasible application implies that the entire TachoSil adhere, TachoSil covers at least 1 cm beyond the margins of the anastomosis line and if more TachoSil sponges are used…
The primary objective of this trial is to demonstrate that aliskiren 300 mg, in addition to standard therapy, has superior efficacy compared to placebo in reducing the primary index of adverse cardiac remodeling (defined as the change in LVESV from…
In this prospective, double-blind, randomized controlled trial, we investigate the hypothesis that regional anesthesia provided by WCI with ropivacaine will reduce pain postoperatively (as measured with COMFORT behavior scale and Numeric Rating…
The goal is to gain more clarity in the wishes of the patient and family members by means of Advance Care Planning with the help of an early outpatiënt consultation of the PACT. This is hoped to show the intervention leads to a reduced number of…
This study investigates whether chemoradiotherapy (45 Gy in 5 weeks with daily cisplatin and capecitabine) after preoperative chemotherapy (3x ECC (epirubicin, cisplatin, capecitabine)) and adequate (D1+) surgery leads to improved survival in…
To assess the effectiveness of continuous, long term (weeks) use of a closed-loop FiO2 control system in comparison with M-FiO2 control in preterm infants with non-invasive respiratory support.
This study has been transitioned to CTIS with ID 2023-505035-12-00 check the CTIS register for the current data
Based on the data as described above, we hypothesize that the FES-PET heterogeneity score can predict progression free survival (PFS) in individual patients prior to start of 1st line endocrine treatment and CDK 4/6 inhibition in ER+ advanced breast…
In this study, we look at how safe the new medicinal product XMT-1536 is for the treatment of ovarian cancer and how well it works. We compare the effect of XMT-1536 with the effect of a placebo. A placebo is a product without the active ingredient…