15 results
The main objective of this study is to assess whether ICD therapy in dialysis patients reduces sudden (arrhythmogenic) cardiac death. The first secondary end point is to compare total mortality death between the two groups. An other is to evaluate…
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
To determine the frequency and suppressive potential of skin resident regulatory T cells isolated from atopic dermatitis and psoriasis patients compared to healthy control subjects (the latter data will be obtained by co-workers at the Brigham and…
We hypothesized that one of the key mechanisms explaining the differences in effect between adalumimab and etanercept on psoriatic skin is that adalumimab, by being a monoclonal antibody like infliximab, is a better inducer of apoptosis resulting in…
Evaluation of pre-operative parameters in order to ascertain the need for a keratoplasty after cataract surgery has been performed in eyes with Fuchs* endothelial dystrophy.
To investigate the prevalence of anemia in EPP patients, related to the severity of symptoms and to investigate the cause of this anemia.
To test the hypothesis stated above, we propose to study the dose-response relationship between various chemostimulants and PMN functions of major trauma patients and patients undergoing major surgery in vitro, both early after the initial trauma or…
The main goal of the study is the identification of the mechanism of obesity related insulin resistance. We will study the relation between the different cell types in visceral and subcutaneous fat tissue and its influence on adipokine proflie.…
The objective of this study is to test the hypothesis that the aspect of neuroticism "irritability" is associated with overactivation of specific brain areas during frustration while the aspect "anxious-depressed" is associated…
This study observes the immune system of children and adults who have been without a thymus for 3 to 30 years. Our objective is to study the role of the thymus in the developing immune system. In addition this study will give insight in the long…
1. estimate the prevalence of MRSA among calve farmers, their families and relevant co-workers at the calve farm;2. determine potential risk factors for MRSA carriage for these groups3. determine the association between MRSA prevalence and types of…
The projects*goal is to gain insight in the pathofysiological processes after trauma that lead to organ failure. The hypothesis is that for the clinical presentation both severe systemic inflammation and severe local injury is needed. In the patient…
The aim of this study is to examine arousals in PTSD, and to investigate the correlation of arousals with nocturnal excretion of hormones of the HPA-axis.
Gain insight into the role of the duodenum in symptom generation in GERD at the mucosal level by comparing several components of the chylomicron-apoA-IV-CCK pathway between GERD patients and healthy subjects upon duodenal lipid load.