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Using patient-derived neurons to investigate the molecular and cellular basis of Major Depressive Disorder

Overall, our primary research goal is to elucidate the underlying molecular and cellular neurobiology of depression. Specifically, this study will focus on the following key objectives:1. My first objective is centered on the major prevailing…

Creation of a disease model system to investigate the mechanisms causing intellectual disability.

1) to gain insight in the pathophysiological mechanisms leading to intellectual disability and 2) to create a model system which allows screening of therpeutic interventions for efficacy.

Determination of complement binding HLA-C antibodies with single-antigen-expressing cell lines (SAL) in pregnancies complicated by preeclampsia

We aim to determine an association between the presence of complement binding anti-paternal HLA-C antibodies and preeclampsia.