91 results
Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…
To assess whether preoperative radiotherapy, as an adjunct to curative-intent surgery, improves the abdominal local recurrence-free survival.
The next questions will be addressed in the present study: 1. Do moderately preterm infants differ in development and attention and concentration capacities from a term and very preterm infants during the first years of life? 2. Do attention and…
To investigate the use of a temporary peginterferon alpha-2a add-on strategy during entecavir therapy in patients with HBeAg-positive chronic hepatitis B by comparing the efficacy of this regimen versus entecavir monotherapy.To evaluate the long-…
The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…
The primary endopoint is to determine whether ketoconazole/octreotide combination therapy, followed by octreotide monotherapy, is an effective treatment for Cushing's disease. Secundary endpoints address the effects of this therapy on bone…
1) To compare (long-term) results of patients treated for Calcific Tendonitis with barbotage, versus patients treated for Calcific Tendonitis with other conservative standard-treatments2) An analysis of group characteristics and risk factors for CaT…
The aim of this study is to estimate the prevalence of late-onset inherited Pompe disease in a large cohort of patients with recently diagnosed obstructive sleep apnea syndrome (OSAS) in two different centres across Europe.
Objective: determine whether a Likert-type scale scoring system, specified for skin irritation reactions (erythema, itching, burning sensation of skin and general irritation of skin) can function as a tool to score the radiation-induced dermatitis…
To determine the best approach for right-sided live donor nephrectomy i.e. to optimise donor*s safety and comfort .
Primary:- assess safety and tolerability and determine the maximum tolerated dose (MTD) of repeated doses or a single dose of AZ01 given as a subcutaneous (SC) or intravenous (IV) dose in healthy subjects. Dosing will not exceed the maximum feasible…
The objective of the study is to measure the extend of voiding symptoms and bother of the urinary tract in young females and to analyse flow patterns and post void residual.
The purpose of this study is to improve the diagnosis and management of hepatocellular adenoma.
The objective of this prospective, observational study is to ensure the safety and the wellbeing of subjects treated with the NEVO* SES.
The aim of this project is to determine the possible use of biomarkers for non or delayed union in long bone fractures of the diaphyseal femur and tibia.
Answer the following questions:1. What are the long term results (>20y) of patients with a primary total knee prosthesis (type Total Condylar) for different endpoints:a. Removal of the prosthesis. (with or without re-implantation)b.…
To measure the differences of DCE MR images between patients with and without local recurrent prostate cancer in the follow up after primary treatment.
The aim of this study is to identify risk factors for various CVDs, i.e. to quantify separate and joint effects of radiation dose to the heart, anthracycline dose, other CT, life style factors, established CVD risk factors and genetic susceptibility…
The objective of this project is to investigate the (cost-) effectiveness of these tailored implementation strategies in comparison to a common used implementation strategy, in a three arm randomized trial.
In this study we want to investigate the effects of sustained hyperglycaemia and hypoxia on the hypoxic pulmonary vasoconstriction and hypoxic ventilatory response