45 results
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
The primary objective of this study is to determine the Optical Density Ratio (ODR) for the prototype CORIMAP camera and compare the ODR values with the Oxymap T1 mounted on a regular fundus camera in a healthy adult population. For comparison, it…
To evaluate whether blood CC12gene expression defines disease status (Stage I-IV, stable or progressive) and whether the blood CC12gene expression predicts response to therapeutic intervention.
The main objective of the panel study is to evaluate the associations between short-term variation of concentrations of key air pollutants (NO2, PM2.5, PM10, and ultrafine particles), measured on a fine spatial and temporal resolution, and short-…
The aim of this study is to develop and validate the ELISA and potential other assays (e.g. LC-MS), in order to measure drug concentration levels. For this, blood and other material will be collected.
to combine and validate diagnostic tests for the prediction of clinical response to therapy with biologics in patients withreumatoid artritis.
Primary objective: Part A: MR cardiopulmonary exercise protocol validation: To validate the protocol of the CMR-ergometer against conventional ergometers in young healthy adultsPart B: CMR exercise study To examine cardiorespiratory structure and…
The primary objective of the study is to determine the effect of food on the uracil and dihydrouracil levels in plasma.Secondary objectives are:* To investigate inter- and intra-individual variations in uracil and dihydrouracil levels in plasma* To…
To describe the pharmacokinetic (PK) profile and effectiveness of sarilumab in patients with pcJIA in order to identifythe dose and regimen for continued development in this population.
The primary objective of the current study is to investigate the effectiveness of MCP-ED in a clinical sample of adolescents with an ED. As a result, this study will provide critical information about the potential relevance of implementing MCP-ED…
Primary Objective: The primary objective is to show that L-theanine has beneficial anxiolytic in healthy individuals. With the current experiment setup that entails the following effects of L-theanine compared to placebo:• Reduced startle effect on…
The primary aim of this study is early identification of sepsis (and septic shock) and cardiovascular instability, based on the hemodynamic profile of ED patients. Continuous noninvasive arterial pressure waveform signals will be collected with the…
The main objective of this study is to compare calcification promoting and inhibiting factors and their interactions in the serum of PXE patients and healthy controls. Secondary objectives (optional) are:1) to identify differences in cognitive…
Primary Objectives: To unravel the immunological characteristics of postoperative recurrent CD and study the immunological changes in the IL-23 pathway following treatment with biological agents.Secondary Objectives:To study clinical, endoscopic and…
To examine cognition, motor function, executive functions, speech and language development, behaviour, psychosocial functioning, academic achievement, physical morbidities and growth of MLPTI at the age of 9 years and correlate this with BSID-III-NL…
Based on the data as described above, we hypothesize that the FES-PET heterogeneity score can predict progression free survival (PFS) in individual patients prior to start of 1st line endocrine treatment and CDK 4/6 inhibition in ER+ advanced breast…
To evaluate existing an currently practiced methods for assessing ocular surface characteristics of DED in order to evaluate their characteristics and comparability.
Primary objective: to investigate MPA exposure in a variety of autoimmune diseases in stable treated patients. Secondary objective: to develop predictive exposure models and evaluate the influence of population covariables on pharmacokinetics .The…
In this study, we look at how safe the new medicinal product XMT-1536 is for the treatment of ovarian cancer and how well it works. We compare the effect of XMT-1536 with the effect of a placebo. A placebo is a product without the active ingredient…
In the present study we aim to investigate the effectiveness of short-term schema group therapy (protocol of de Jager and Burger) on (1) persistent anxiety and depressive symptoms, and (2) dysfunctional schemas, experiential avoidance and the mode…