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A novel class of regulators: the potential of IL-10 producing B cells in decreasing allergic inflammation in asthmatic patients.

Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…

Augmenting response to entecavir using a temporary peginterferon alpha-2a add-on strategy for the treatment of HBeAg-positive chronic hepatitis B (ARES study)
- Long-term follow-up of a peginterferon alpha-2a add-on strategy in chronic hepatitis B patients treated with entecavir

To investigate the use of a temporary peginterferon alpha-2a add-on strategy during entecavir therapy in patients with HBeAg-positive chronic hepatitis B by comparing the efficacy of this regimen versus entecavir monotherapy.To evaluate the long-…

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

Double-blind, placebo-controlled, multiple ascending-dose study to investigate the safety and tolerability of AZ01 in healthy volunteers.

Primary:- assess safety and tolerability and determine the maximum tolerated dose (MTD) of repeated doses or a single dose of AZ01 given as a subcutaneous (SC) or intravenous (IV) dose in healthy subjects. Dosing will not exceed the maximum feasible…

Micturition symptoms and uroflowmetry in young adult females

The objective of the study is to measure the extend of voiding symptoms and bother of the urinary tract in young females and to analyse flow patterns and post void residual.

An Observational Safety Evaluation of patients treated with the NEVO* Sirolimus-eluting Coronary Stent.

The objective of this prospective, observational study is to ensure the safety and the wellbeing of subjects treated with the NEVO* SES.

DCE MRI in the follow-up of prostate cancer patients after radiotherapy; a matched case control stuy (Pilot)

To measure the differences of DCE MR images between patients with and without local recurrent prostate cancer in the follow up after primary treatment.

A Clinical Safety and Efficacy Comparison of NEVANAC® 0.1% to Vehicle
Following Cataract Surgery in Diabetic Retinopathy Patients

Demonstrate superiority of NEVANAC® (nepafenac ophthalmic suspension) 0.1% relative to nepafenac vehicle based on the percentage of diabetic retinopathy patients who develop macular edema (defined as >=30% increase from pre-operative baseline…

Child Abuse Inventory at Emergency Rooms (CHAIN-ER); Detection of Child Abuse at Emergency Rooms in Utrecht (the Netherlands): effective?

1. to provide data in children presenting with physical injury at EDs on the predictive value of Sputovamo2. to address the added predictive value of early phase inquiry with other health care providers in establishing a diagnosis of child abuse

Imaging of tendon properties of the hand

The general aim of this study is to develop and evaluate imaging techniques of tendon properties of the hand that can be used in clinical studies or standard clinical care in patients with flexor tendon injuries. Specific aims:1. Develop a protocol…

Radioactive holmium microspheres for the treatment of patients with non-resectable liver metastases of mixed origin; a single center, interventional, non-randomized, open label, safety study.

Primary objective:To establish the safety and toxicity profile of treatment with Ho-166-PLLA-MS.Secondary objectives:• To evaluate tumor response. • To evaluate patient dosimetry. • To evaluate performance status.• To evaluate Quality of Life (QOL…

Does physical exercise increase clotting factor VIII levels in patients with moderate or mild haemophilia A ?

The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.

A phase I/II, open-label, dose-escalating study to evaluate the safety, tolerability and pharmacokinetics of twice daily oral midostaurin and to evaluate the preliminary clinical and pharmacodynamic response in pediatric patients with relapsed or refractory leukemia

This is a phase I/II pediatric dose-ranging study that will evaluate the safety, tolerability and pharmacokinetics of midostaurin in children <18 years of age and >= 3 months who have relapsed or refractory leukemias that may benefit…

Posture or Patching (PoP). Accelerated clearing of the media with massive vitreous hemorrhage and suspected retinal tear.

Objective: To investigate whether binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants or not.

Detailed and consistent clinical and immunological monitoring of patients with Rheumatoid Arthritis who are treated with biological agents.

The proposed study aims to develop a prediction rule for response to biological treatment in RA (i.e. effectiveness and adverse events). Guidelines for treating the disease with biologicals using the (derived) prediction rules will be defined. To…

Long-term safety of trastuzumab in patients with HER2-positive breast cancer

Primary objective • To explore changes in left ventricular ejection fraction (LVEF) values before, during and after trastuzumab treatment Secondary objectives• To explore the reversibility of congestive heart failure associated with trastuzumab…

NAVA on the PICU and NICU: Feasibility study with children needing mechanical ventilation

Feasibility study of the option NAVA (Neurally adjusted ventilatory assist) on the Servo-i in ventilated children in the age of 0-18 on the PICU and the NICU of the Erasmus MC -Sophia Childrens hospital in Rotterdam.

Effect of Statins on Sympathetic Activity in Hypertensive Patients with Chronic Kidney Disease: a Randomized trial in Hypertensive Patients with Chronic Kidney Disease

The central hypothesis of this project is that atorvastatin (added on standard antihypertensive treatment ARB) causes a substantial decrease in MSNA in hypertensive patients with CKD.

Standard and novel echocardiographic imaging techniques to assess cardiac dyssynchrony in pediatric patients with cardiac disease

Routine evaluation of dyssynchrony in pediatric patients with cardiac disease is feasible using standard and novel echocardiographic techniques. The extent of cardiac dyssynchrony and its influence on cardiac function differs between groups of…

3D Transperineal Ultrasound Imaging of the changes of the pelvic floor muscles during labour

Primary Objective: 3D ultrasound imaging of the morphological changes of the pelvic floor and the arising of possible defects during labour.