703 results
The objective of this study is to contribute to evidence based intervention to optimize dental care for preschool children, and deliver evidence of feasibility and (cost-)effectiveness of this innovative intervention in which an oral health coach is…
The main objective of this study is to evaluate the image quality of a new cone-beam CT imaging system that will be used to acquire images of a wide selection of anatomical locations in patients receiving radiotherapy for cancer.
Primary objectivesCohort 1 Estimate the efficacy of nivolumab treatment in patients with relapsed/refractory ALK+ ALCL in terms of best objective response rate within thefirst 24 weeksCohort 2 Estimate the efficacy of nivolumab treatment as…
To evaluate the efficacy and safety of EHSG-KF in comparison to meshed STSG in children with partial deep dermal and full thickness burns. Primary Objective: To evaluate the efficacy of EHSG-KF in comparison to meshed STSG based on:• Ratio of…
The current study aims to recruit a greater number of lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to…
The aim of this study is to investigate in patients with metastatic HER2 positive or HER2-low breast cancer whether a PET scan with a new HER2 tracer ([89Zr] DFO*trastuzumab) accurately depicts all abnormalities and whether ultimately this HER2 PET…
The purpose of this study is to characterize the safety and tolerability of OAV101 IT in participants who have discontinued treatment with nusinersen (Spinraza®) or risdiplam (Evrysdi®). The data from this study will expand on the data generated…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
To obtain insight whether skeletal muscle adaptations can explain post-exertional fatigue malaise in patients with PASC and ME/CFS, the present study will address the following objectives: Primary objectives:• To determine markers for skeletal…
Primary Objective: 1) To assess determinants of circulating MNP levels in Dutch females of reproductive age, including the relative contribution of indoor sources, food packaging and preparation methods to MNP and plastic-associated chemical body…
In the DETECT-2 study, we aim to construct an algorithm for detection of cardiac arrest related falls using wrist-derived accelerometer signals from simulated sudden falls and non-fall movements. The sensitivity and false positive rate of the…
The goal of this study is to investigate the most optimal way of canola protein processing on blood plasma amino acid responses in young females.
Our objective is to compare the efficacy of early chest tube removal combined with single-shot PVB versus standard treatment (chest tube for at least 3 days and thoracic epidural analgesia (TEA)) after surgery for PSP. Efficacy is defined as proving…
Primary objective: To determine whether there is an overall survival benefit for patients with an intermediate risk breast cancer from chest wall irradiation following mastectomy, in addition to treatment with optimal modern systemic therapy.…
Primary safety objective: The primary safety objective of the study is to assess the safety of the Apreo Endobronchial System for treatment of severe emphysema.
This is an exploratory study to assess the presence, specificity, type and strength of systemic and local specific cellular immune responses in patients with lung adenocarcinoma at different time-points during routine diagnostic work-up and…
To characterize the molecular mechanisms underlying parasympathetic regulation of adipose tissue.
The objective of the RAAK study is to collect bloed and joint tissue (cartilage, ligaments and subchondral bone) of patients that undergo a total joint replacement due to a endstage OA. Genomic material (DNA and RNA) will be isolated from both the…
The objective in the vanguard phase of the LIMIT trial is to assess the feasibility of recruiting 400 subjects over approximately 3 years at 5 centres. The objectives in the full trial are to evaluate the safety and efficacy of a common, lower INR…
The aim of this research project is to study a large a group of patients with tonic dystonia longitudinally, to accurately describe the phenotype, to investigate the potential underlying mechanisms and to identify possible causes and risk factors.