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An open label, multi-center roll-over study to assess long-term effect in pediatric patients treated with Tafinlar (dabrafenib) and/or Mekinist (trametinib)

This study has been transitioned to CTIS with ID 2023-509276-42-00 check the CTIS register for the current data. Primary:To assess the long-term safety of treatment with dabrafenib, trametinib or the combination.Secondary:To assess the long-term…

Dose reduction of the new generation biologics (IL17 and IL23 inhibitors) in psoriasis: A pragmatic, multicentre, randomized, controlled, non-inferiority study - BeNeBio study

The primary goal is to investigate whether controlled dose reduction of IL17 or IL23 inhibiting biologics is not inferior compared to usual care. This is measured by comparing the proportion of long-term disease flares between the two groups (dose…

Accelerated 23-hour ERAS care for colon surgery.

The aim of this study is to investigate the feasibility and safety of a 23-hour accelerated ERAS protocol for patients undergoing colorectal surgery. In this accelerated ERAS protocol, patients undergoing colorectal surgery will be discharged within…

EMDR Flash Forward as an intervention on the mental images of worst case scenarios in paranoid delusions

Primary Objective: Investigate whether EMDR Flash Forward is an effective intervention to process the mental images of worst case scenarios that occur in paranoid delusions, in order to decreases the preoccupation with the delusion.Secondary…

MyLeg P1: The functional evaluation of a ankle prosthesis prototype for osseointegrated transfemural amputees

To evaluate the performance of the newly-developed prosthesis (prototype) during walking in people with a transfemoral osseointegration implant. This will be done using lab-based measurement, evaluating metabolic cost, walking capacity, gait pattern…

Pain processing in PTSD - Investigating neural correlates of dissociative analgesia

The current study aims to elucidate neural correlates of pain processing and dissociative analgesia in PTSD. To this end, we want to replicate the pilot study by Mickleborough et al., (2011) and test the functional pain processing protocol with…

rotational ThROmboelastometry in Patients at risk for disseminated Intravascular Coagulation*

The aim of this study is twofold: 1) to measure ROTEM profiles in patients at risk for DIC to determine cut off values of ROTEM corresponding to the currently used International Society for Thrombosis and Haemostasis (ISTH) DIC scores, as well as to…

Trauma-focused exposure therapy for posttraumatic stress disorder in patients with eating disorders

The current study is an initial evaluation of the feasibility and effects of exposure therapy in those suffering from ED and comorbid PTSD.

A multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the prevention of ischemic stroke in male and female participants aged 18 years and older after an acute non-cardioembolic ischemic stroke or high-risk TIA

This study has been transitioned to CTIS with ID 2023-503793-20-00 check the CTIS register for the current data. The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who…

A Two Part Phase IIa/b Multicentre, Randomised, Double-Blind,
Placebo-Controlled, Parallel Group Dose-ranging Study to Assess
Efficacy, Safety, and Tolerability of the Combination of
Zibotentan and Dapagliflozin, and Dapagliflozin Monotherapy
Versus Placebo in Participants with Cirrhosis with Features of
Portal Hypertension

This study has been transitioned to CTIS with ID 2023-505405-17-00 check the CTIS register for the current data. The main objective of this Phase IIa/b study is to demonstrate the effectof zibotentan on HVPG, and that dapagliflozin can mitigate…

An open, prospective, multicenter investigation to evaluate the clinical outcome of PrimeTaper
EV implant in extraction sockets and healed ridges - A 5 year follow-up

1. Primary objectiveThe primary objective of this clinical investigation is to evaluate implant survival rate 1 year afterpermanent restoration (PR), i.e. implant in place 1 year after PR, Yes/No.2. Secondary objectivesThe secondary objectives are…

Surgery and exercise versus exercise only for chronic patellofemoral pain syndrome: a randomised controlled trial.

Zie het onderzoeksprotocol 2: "Objectives".

Interventional, randomized, double-blind, parallel-group, placebo-controlled study of add-on eptinezumab treatment to brief educational intervention for the preventive treatment of migraine in patients with dual diagnosis of migraine and Medication Overuse Headache

This study has been transitioned to CTIS with ID 2024-510729-24-00 check the CTIS register for the current data. Primary Objective• To evaluate the efficacy of eptinezumab as add-on to BI for the prevention of migraine and treatment of MOHSecondary…

Effect of Automated Closed-loop Ventilation versus Conventional Ventilation on Duration and Quality of Ventilation (*ACTiVE*) -a randomized clinical trial in intensive care unit patients

To compare automated closed-loop ventilation (INTELLiVENT-ASV) to conventional, non-automated ventilation in patients in the ICU.

Palliative Sedation across European settings - a prospective observational multicentre study

• To evaluate the effect of palliative sedation on patients comfort and other symptoms in different international hospices, palliative care units and hospital ward settings.• To assess the clinical practice of palliative sedation in different…

Non-invasive assessment of oral leukoplakia and adjacent tissue

Our primary objective is to determine how often and to what extent potentially pre-malignant oral fields extend beyond their visible lesion. If those "underestimated" lesions have a greater chance to recur, narrow band imaging-guided…

Effectiveness of Hospital Fit on physical activity of hospitalised patients: a stepped-wedge cluster-randomised clinical trial and process evaluation.

Primary: to investigate the effectiveness of using Hospital Fit as part of the physiotherapy treatment on average time spent walking per day in patients hospitalised at the Medical Oncology or Cardiology Departments of the Maastricht University…

A Phase 1b/2a, Open Label Trial Evaluating the Safety, Pharmacokinetics, and Efficacy of EP-104IAR in Adults with Eosinophilic Esophagitis (RESOLVE)

This study has been transitioned to CTIS with ID 2024-516689-13-00 check the CTIS register for the current data. The primary objectives of this study are:• To determine the safety, tolerability, and RP2D(s) and regimen(s) of EP 104IAR• To determine…

Phase II randomised controlled trial of patient-specific adaptive versus continuous Abiraterone or eNZalutamide in metastatic castration-resistant prostate cancer: the ANZadapt study

The primary objective is to investigate whether the patient-specific adaptive treatment with AA/ENZ leads to a superior time to time to treatment failure (TTTF) while on treatment compared to continuous treatment with AA/ENZ. Secondary/tertiary…

Extreme phenotype social jetlag study

The objective of this study is to investigate which pathways explain the association between social jetlag, insulin sensitivity and glucose metabolism in people with prediabetes with and without social jetlag.