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European Fans in Training (EuroFIT): A multicentre randomised controlled trial of a gender-sensitised programme to increase physcal activity and reduce sedentary time delivered to men aged 30-65 in elite European football clubs

The main aim of the EuroFIT trial is to assess the effectiveness and cost-effectiveness of the EuroFIT programme in supporting men to achieve an increase of at least 1000 steps per day (about 10 minutes on average per day, or 70 minutes per week)…

Phase III Randomized Double-Blind Trial of Bepanthen® Cream Versus Cetomacrogol Cream in the Prevention of Papulopustular eruption in Patients Receiving Epidermal Growth Factor Receptor Inhibitors (EGFRI): BeCet

To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…

Bone density in apheresis donors compared with blood donors. A pilot-study.

To investigate whether bone mineral density is lower in apheresis donors than in blood donors.

PRognostic hEModynamIc profiling in the acUte ill eMergency department patient: PREMIUM registry

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The effect of vitamin D-supplementation on insulin sensitivity in non-western immigrants in the Netherlands

To assess whether supplemention of vitamin D3 (1200 IU/day) in vitamin-D deficient non-western immigrants at risk for type 2 diabetes mellitus can improve the insulin resistance and betacell function as well.

Improving risk assessment in consanguineous couples by means of SNP analysis

The objective of this research is to develop a method which can identify among all consanguineous couples the ones which are at high risk.

PRODEO: PROfylactic Haloperidol in patients defined as high risk for DElirium with delirium risk mOdel

Research questionWill prophylactic administration of haloperidol to patients with a high risk of developing a delirium according to DEMO, reduce the incidence of a delirium? HypothesesProphylactic administration of haloperidol in post-operative…

Preservation of ovarian cortex tissue in girls with Turner syndrome:
A multicenter exploratory intervention study

To investigate the occurrence of live birth in women with TS after ovarian tissue cryopreservation in childhood followed by auto transplantation in adulthood.

A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Adolescent Patients 12 to 17 Years of Age with Chronic Migraine - the REBUILD-2

This study has been transitioned to CTIS with ID 2023-505835-11-00 check the CTIS register for the current data. PrimaryTo demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in an adolescent population (12 to 17…

Genetic Clopidogrel response testing to finetune the antithrombotic regimen in (D)OAC Treated patients undergoing PCI

This study has been transitioned to CTIS with ID 2024-512350-17-01 check the CTIS register for the current data. The aim of this study is to evaluate the feasibility and safety of CYP2C19-genotype-guided p2y12 inhibitor selection in patients who are…

A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Patients 6 to 17 Years of Age with Episodic Migraine - the REBUILD-1

This study has been transitioned to CTIS with ID 2023-505836-36-00 check the CTIS register for the current data. Main Objective:To demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in (at least) 1 of the…

Comparison of clinical and radiographical outcomes following placement of hybrid and moderate rough implants in the posterior mandible of periodontally compromised patients: a 3-year randomized clinical trial

Thel aim of this project is to analyse hybrid implants placed in de posterior mandible of periodontally compromised patients and to compare the treatment outcome of either moderate rough or hybrid implants.

Psychotic Experiences in Young Adults

Aim of this assessment is to explore the course (persistence, remission and onset) of AH and to investigate associations with other psychic experiences, anxiety and depressive symptoms, risk factors (trauma, cannabis), protective factors (coping…

The THYRO-Dynamics study: Is the dynamics of thyroid hormones during cancer treatment in children adaptive or disruptive? - a prospective evaluation

This prospective evaluation of the dynamics of thyroid hormones during cancer treatment in children is designed to determine the prevalence of thyroid hormone deficits at diagnosis, during and directly after treatment and to study changes in thyroid…

Heading in football: impact on neural blood biomarkers

To determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting.

Effect of protein supplementation on fat free mass preservation after bariatric surgery, a randomized double-blind placebo-controlled trial.

The main aim of this study is to assess whether protein supplementation could prevent excessive fat free mass loss during the first year after bariatric surgery.

KopOpOuders for PTSD: Randomized controlled trial of a blended care preventive parenting intervention for parents with PTSD.

Main objective: to test the effectiveness of KOO-PTSD on parenting skills at the macro- and micro-level.Secondary objectives: to test the effectiveness of KOO-PTSD on perceived parenting competence, social support, parenting stress, child…

FiberUP in clinical practice

To investigate the feasibility of increasing preoperative dietary fiber intake in CRC patients undergoing surgery via 1) personalized dietary advice (Vezel-UP tool), or 2) vegetable product containing natural fibers (WholeFiber) compared to 3)…

An explorative and experimental study to assess the feasibility, acceptability, and effectiveness of early intervention with light, lifestyle and ImCT therapy in individuals at risk for severe mental illness

In the current study, the feasibility, acceptability and effectivity of a new add-on early intervention program for individuals at risk for the development of bipolar disorder is evaluated. This intervention program entails psycho-education, light…

Online and offline child sexual offenders: Who are they and what strategies do they use?

The first objective is to investigate who the PMSA are, what strategies and motives they use to approach minors online, what sexual activities they do on the Internet and whether they are satisfied with their (sexual) wellbeing. The second objective…