136 results
To investigate lesion detection in patients with liver metastases of colorectal cancer with [18F] FLT-PET compared to CT at baseline (= gold standard). This investigation will be done based on a qualitative assessment of the scans ([18F] FLT-PET and…
Evaluate the safety and effectiveness of four cementless Taperloc versions: Taperloc Complete Reduced Distal and Taperloc Legacy Full Profile Reduced Distal compared to Taperloc Complete Full Profile and Taperloc Legacy Full Profile in primary THA.
To investigate the long term stability (> 5 yrs) in patients treated with mandibular distraction osteogenesis (MDO) for correction of a Class II-occlusion. Hypotheses:1) MDO is a technique for mandibular lengthening with comparable stability…
To evaluate whether no utilization of compressive stockings is as effective as wearing a Class II Thrombo Embolic Deterrent (TED) stocking for 4 hours. Primary outcome is leg volume on post-operative day 14.The secondary objective is to study the…
To test the cost-effectiveness of the psycho-educational intervention HypoBewust (HB) compared to care as usual.Research questions:1) Does HB significantly improve a) health related outcomes and b) societal costs after 6 months?2) Are the expected…
To assess the effect of an infant formula with an optimized amino acid composition and a lower total protein content during the first four months of life on infant growth. Amendment follow-up study: To assess the long term effect of the intake of an…
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
To investigate the effects of a 5-day diet with 30% caloric and 70% protein restriction on cardiotoxicity induced by anthracycline treatment in women with triple negative or hormone receptor-positive breast cancer. The biomarker high-sensitivity…
To evaluate local complement activation/depositions after intradermal LPS challenge
To assess the kinetics of EVs in standard HD, derived from both in- (BI) and outside (TI) the ECC.
The aim of the study is to map the changes that occur in breast tissue composition during pregnancy, lactation and post-lactational involution. The secondary aims are to:• validate the performance of diffuse optical spectroscopic imaging (DOSI)…
The primary objective of this study is to objectify the efficacy of TORS compared to CPAP and MAD. Secondary objectives:To determine long term outcomes of TORS compared to CPAP or MAD.To compare functional sleep outcomes in TORS and CPAP/MAD…
In different stages of HCM, to measure the: - Myocardial perfusion- Myocardial function- Volume parameters of the heart- Fibrosis- Function of the small vessels (endothelial (dys)function)- Diastolic function and strain of the heart
To explore the effect of additional protein in plant-based drinks. In addition, gastric protein coagulation will be examined for one of the plant-based drinks and compared to that of bovine milk.
To sequence the GBA1 gene in Parkinson*s disease patients to identify possible participants for a possible future phase 1 trial. The gene will be described as wildtype (WT) or containing a mutation (GBA+); with record of the specific mutation. To…
RED-LRGP: To investigate the yield of a screen-like early diagnosis strategy as compared to usual primary care in terms of the number of newly diagnosed coronary artery disease, atrial fibrillation, and heart failure in community people aged 50-80…
In this study we will compare three dosage forms (products) of cannabidiol (also known as CBD): tincture (extract), shot, and chew.We will compare how quickly and to what extent cannabidiol in the different dosage forms is absorbed, transported, and…
The primary objective is to explore phenotypes of (sub)clinical PMDD and explore the impact of (sub)clinical PMDD on the lives of the affected women.The secondary objective is to assess the validity of a Dutch translation of the self-administered C-…
The main goal of this study is to determine motor, cognitive, behavioral, executive, and language functioning of children with PAIS at school age. Furthermore, we will analyze the effect of PAIS on brain growth, development, and connectivity using…
Our primary objective is to investigate the change in dyspnea severity after 4 weeks of the use of the PEP-buddy. Secondary objectives are to investigate the patient satisfaction level and use of the device, the effect on quality of life and COPD…