121 results
The objective of this study is to investigate if CEC are elevated in SCD (and if they could therefore serve as a potential tool for assessing SCD activity), and what the relation of CEC is to the patients medical history and to specific laboratory…
The primary aim of this study is to validate a screening instrument for ophthalmologic disorders using full, in depth ophthalmologic assessment as the gold standard. Secondary aims include:* To study the severity and clinical impact of different…
The aim of this study is to determine the levels of hemostasis factors after an uncomplicated pregnancy.
4.1 Primary• To estimate the Sensitivity and False Positive rate of OTL38 for malignancy detection during Near Infrared Imaging (NIR).• To assess the safety and tolerability of single intravenous doses of OTL384.2 Secondary• To assess the safety of…
The objectives of the proposed research are: (1) to characterize the neural correlates of verbal learning abilities (both for nouns and verbs) in typically developing (TD) children compared to children with DLD, aged 8-12 years old. (2) to…
The aim of this project is to validate 3 novel biomarkers (FDG PET/CT, WES and NGF). The utilization goal is to implement these biomarkers afterwards in clinical practice to rationalize treatment strategies. The primary objective is to validate the…
PRIMARY OBJECTIVETo assess the diagnostic performances (specificity, sensitivity, positive and negative predictive values) of monitoring blood biomarkers (T-Ag antibodies and miR375 levels) for detection of recurrence of disease during follow up.…
The primary objectives of this study are to: (i) derive quantitative measures of behaviour on the basis of smartphone monitoring in a healthy cohort and a cross-diagnostic cohort of patients with mental disorders (e.g. depression, anxiety and…
1) To determine whether advanced MRI techniques can detect active inflammatory Gd enhancing lesions. 2) To determine whether blood biomarkers are associated with the presence of enhancing brain lesions in MS. 3) To determine whether advanced MRI…
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
Primary objectives• To identify the percentage of patients in which a drug resistant clone can be detected with ctDNA before the emergence of radiological progression.• To determine the success rate of crizotinib and osimertinib combination…
Primary objective: The primary objective of this non-randomized intervention trial is to investigate whether TAVR improves exercise capacity in patients with preserved LVEF and NF/LG or LF/LG severe AS reclassified based on hybrid CT/TTE-derived…
We aim to identify diagnostic serum metabolite and protein biomarker signatures for early detection of cancer in asymptomatic high-risk population and prognostic biomarkers for selection of patients with poor prognosis.
The main objective is to define the self-test performance by means of the Total Error for the Medimate Minilab 2017 for the set of parameters.
The primary objective of this study is to investigate the accuracy and reliability of ultrasound scoliosis measurements and progression of the curve and to correlate these outcomes with the standard radiographic measurements obtained at the same…
Primary Objective:Efficacy:· Evaluate the efficacy of subcutaneous (sc) azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in the defined study population.Secondary Objectives:Safety:· Assess the safety and…
The primary objective of this study is to optimize the ultrafast ultrasound flow imaging technique for intra and extra cardiac flow visualization in neonates. The secondary objectives are 1) to compare cardiac output determined using conventional…
This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, as administered by the nasal route, in neonates who suffered from PAIS. The ultimate goals of the present study is therefore to develop a therapy using adult human…
To study the value of sonographic features including vascularity in the prediction of fibroids* volume change at follow-up during their (1) natural course or (2) long-term use of exogenous hormone exposure; after initiation of (3) SPRMs e.g. Esmya…
Before embarking on a study using MRDTI as sole test to manage clinically suspected UE-DVT, we need to perform a study to determine whether the test has the potential to be useful in patients with suspected UE-DVT. This study has the objective to…