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Effectiveness of a personalized eCoach for cardiovascular risk management targeting primary prevention in general practice*

The objective of the study is to evaluate the benefit of the eCoach in the general practitioner*s office within cardiovascular risk management. Specifically, the eCoach evaluates the effect on individual risk factors and the risk on developing…

High intensity interval training in patients with a right ventricle to pulmonary artery conduit

Primary Objective: To assess the efficacy, expressed by change in peak oxygen consumption obtained with cardiopulmonary exercise testing (CPET), of a HIIT program in patients with an RV-PA conduit.Secondary Objective(s): To determine predictors for…

Abdominal Aneurysm in Motion
Physical therapy for patients with an indication for AAA repair; a pilot, correlation study

The main objective is to study to separate patients who benefit from training, from patients who do not benefit from training and identify factors that impede training capability. Secondary objective if training leads to change of aerobic fitness (…

CONNECT2GROW-UP; Screening, monitoring and care network in families with a
parent with a psychiatric disorder

In this project, we will conduct research within a learning and development framework to explore the barriers in adult mental health care (V-GGZ) and how and when screening and monitoring for KOPP (Children of Parents with Psychiatric Problems) can…

Pilot study on Ketosis Impact on Signs and Symptoms of Schizophrenia and Bipolar Disorders

The current pilot study intends to establish the effect of a single dose of dGK on relevant (neuro-)electrophysiological (primary outcome: Pre-Pulse Inhibition (PPI); furthermore on resting EEG, on the ERP P300, cognitive, metabolic, inflammatory,…

Acute effects of ketone monoester supplementation on brain function in older men with overweight

The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on (regional) brain vascular function and insulin-sensitivity, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-…

Early variations of immune aging: the EVIA-NL study

The aim of this study is to characterize the immune system and its changes over time. We aim to identify the factors that influence the kinetics of immune system aging, to describe potential aging endotypes in different individuals, and correlate…

Changes in body composition, dietary intake, and physical activity in children with cancer - a master protocol

The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…

Towards the primary prevention of hip OA - pilot study

The primary objective of the current pilot study will be to assess the feasibility of participant selection methods to identify individuals with cam morphology free of hip OA.Secondary objectives includea) the evaluation of the willingness of…

AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

The purpose of the pivotal study is to determine the safety and efficacy of IMPEDE-FX RapidFill for increasing the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label EVAR stent graft…

Effect of oat-coated disposable gloves compared to non-coated disposable gloves, in health care workers, with high glove consumption, on skin condition and user experience.

Usability of oat-coated gloves (intervention) and the effect on skin condition in comparison to non-coated gloves (care as usual).

Insight into the prevalence of unruptured intracranial aneurysms in a targeted risk-factor population: towards targeted screening

Primary objective:- Determine the number of unruptured IAs in smoking women aged 50-60 years in the Dutch population in a cohort of 55 participants. Secondary objectives:- Evaluate the possible changes in quality of life associated with a screening…

The effect of a single session of whole-body neuromuscular electrical stimulation (NMES), with or without subsequent intake of a protein bolus, on whole-body protein turnover in sedated intensive care unit (ICU) patients

To examine the effect of a single session of whole-body NMES, with or without subsequent protein intake, on whole-body protein turnover

PROFID EHRA
PRevention Of sudden cardiac death aFter myocardial Infarction by Defibrillator im-
plantation

To demonstrate that in post-MI patients with symptomatic heart failure who receive optimal medical therapy (OMT) for this condition, and with reduced LVEF <=35%, OMT without implantable cardioverter defibrillator (ICD) implantation (index…

A web based cognitive behavioral therapy that addresses gender
dysphoria, gender minority stress and suicidality among gender minority youth. A Randomized Control Trial

Research question:To what extent is a web-based, Cognitive Behavioral Therapy (CBT) specially designed for young gender diverse youth in the Netherlands, an effective treatment to reduce their suicidality? Are there gender, sex assigned at birth,…

Randomized, double-blind, sham-controlled trial to investigate combined occipital and supra-orbital neuromodulation in resistant migraine. The RECLAIM study.

To evaluate the safety and performance, including clinical benefit, of the PRIMUS System for the treatment of Resistant Migraine.

Personalized hemodynamic management targeting preoperative baseline cardiac index in high-risk patients having major abdominal surgery: the international multicenter randomized PELICAN trial

To investigate whether personalized hemodynamic management targeting baseline cardiac index reduces the incidence of a composite outcome of acute kidney injury, acute myocardial injury, non-fatal cardiac arrest, severe infectious complications, and…

LIGHT (Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial): Secondary prevention of dementia in memory clinics: implementation and (cost-) effectiveness of an integrated lifestyle intervention

The primary objectives are to examine both the (cost-)effectiveness of an innovative 1-year lifestyle intervention on lifestyle change measured by the validated Lifestyle for Brain Health Score (LIBRA) in older adults with a subjective cognitive…

Feasibility of Pre-emptive VACStent Placement after Ivor Lewis Esophagectomy, to Prevent Anastomotic Leakage (PREVENT feasibility study)

We aim to evaluate the technical and logistic feasibility and safety of pre-emptive VACStent placement in patients undergoing esophagectomy with gastric conduit reconstruction, to prevent anastomotic leakage by early endoscopic vacuum therapy (EVT…

PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients

The primary objective is to show that brain MRI surveillance alone is non-inferior in terms of overall survival (OS) to brain MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).