24 results
Primary: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on protein synthesis rates in Hoffa*s fat pad, synovium, bone, ligaments, menisci, and cartilage in older adults with knee osteoarthritis…
We aim to lay the fundament of novel interventions by gaining an in-depth comprehensive understanding of individual differences in the overnight adaptation of emotional memory and malleability thereof by noradrenergic modulation.
Primary Objective:1. Turnover rate of antigen-specific cells (group I)2. Turnover rate of functional T-cell subsets (group II)Secondary Objective(s):• Determining absolute numbers of antigen (poliovirus, measles, Hepatitis A and Hepatitis B)…
The current study describes the Rotterdam Cohort (i.e., a sub-project) of the larger Growing Up Together in Society Project, which has the aim to examine combined social contextual, biological, and behavioral mechanisms that drive the transitions…
In this study we aim to answer the question whether TCR diversity becomes limiting at older age and thereby leads to impaired responses to novel antigens. While many studies have suggested a contraction in TCR diversity with age, a one-to-one…
Our primary objective is to elucidate the neural and cognitive effects of short-term TUS to two thalamic subdivisions in humans. To this end, we target two thalamic subregions that are spatially adjacent yet feature divergent connectivity profiles…
To investigate the frequency of V*9Vδ2-T cells in patients with metastatic castration-resistant prostate cancer
The perception of adult females diagnosed with CAH, who underwent genital surgery in childhood, on early feminizing surgery.
The primary goal of this phase 0 study is to assess the variability of mitochondrial function measurements in healthy volunteers and PD patients.
This study aims to elucidate the relationship between subjective controllability and dopamine in PD patients. We hypothesize that lower levels of dopamine will be related to lower estimations of controllability. Using fMRI, we will investigate the…
Our main goal is to clarify the behavioural and neurophysiological effects of short-term TUS on deep brain circuits in humans. We will compare the effects of Amygdala-TUS, dACC-TUS and sham-TUS to one-another using a behavioural task and fMRI. Our…
Primary Objectives• To evaluate prognostic factors of disease progression in subjects with Stargardt disease secondary to mutation in the ABCA4 gene • To further characterize the STGD1 patient population for future interventional clinical studies
To compare the plasma concentration versus time profiles and postprandial bioavailability of DHA and EPA after a nutritionally relevant oral dose of 1.1 gram (expressed as DHA + EPA) administered as either CCx gelatin-based soft chews (emulsified)…
The main objective is to explore whether digital features of dysarthria, dysphonia, proximal arm fatigue and ptosis can differentiate between participants with and without MG.
To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age
The main aim of the current study will be to determine the metabolic fate of dietary protein. More specifically, the main aim is to assess the incorporation of protein-derived amino acids in a wide variety of organ tissues in vivo in humans.
To develop a FOG prediction algorithm under free-living conditions, and to test evaluate the use of the Parkinson*s Vibrating socks under the same conditions
To investigate the effect of PB HEHP ONS compared to DB HEHP ONS on nutritional intake (energy & protein) in subjects with or at risk of DRM and/or prescribed with ONS.
This empirical-philosophical project aims to provide new ways of making sense of the chronicity or timelessness of chronic pain of young people aged 16-25. By combining philosophical reflection with qualitative research, it will decipher 1) how…
Primary objective:The primary objective is to answer the following research question:1. How do people who transitioned to psychosis describe alterations in their experiences of self and reality prior to the first psychotic episode? 2. Are these…