29 results
To study the relation between bone regulating and bone turnover markers and:a) bone mineral density measured by DEXAb) disease activity measured by BASDAI, ASAS response criteria and laboratory assessments (CRP and ESR)c) physical function measured…
The primary objective of the study is to determine whether AVIM therapy in combination with medical therapy is more effective at reducing ambulatory systolic blood pressure (aSBP) and to determine whether AVIM therapy is safe.
The objective of this study is to demonstrate the clinical performance of VENTANA PD-L1 (SP263) CDx Assay in terms of its ability to identify patients with metastatic NSCLC who may benefit from treatment with acasunlimab (GEN1046) in combination…
Primary objectives1. To determine the effect of a tailored exercise program by using the widely implemented exercise app *Physitrack* on experienced pain and fatigue in patients with FSHD.2. To investigate the relationship between perceived pain and…
To evaluate the acceptability and effectiveness of a deepfake victim-perpetrator confrontation in young adults with sexual violence-related PTSD.
The main objective of this study is to determine the maximum tolerated dose (MTD) of 5 fractions MRgRT for patients with AC following FLOT therapy. The secondary objectives are feasibility, non-dose limiting toxicity, oncological outcomes and to…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
The purpose of this study is to determine the feasibility of sports-specific CTR in athletes.
Primary Objectives are to• identify novel (likely) pathogenic genetic variants in familial or young AF patients.• investigate the relation between genetic profiles and electrical (AF) phenotypes.• develop a specific gene panel for AF• construct a…
This study has been transitioned to CTIS with ID 2024-520305-39-00 check the CTIS register for the current data. Primary objective: to evaluate the efficacy of LSD 25µg every 3 days for 3 weeks in cCH. Additional objectives:- To evaluate the safety…
The aim of this clinical study-part in the Netherlands is to identify demographic and clinical predictors of risk, diagnosis, and progression of heart failure. In the European study component, the objective is to eventually compute with this…
To investigate the influence of body posture on the measurement cervical sagittal balance parameters.
We aim to reduce total scan time and accelerate the conventional acquisitions in patients presenting with cardiovascular disease by evaluating the novel developed non BH 3D cardiovascular scan technique and the use of the adaptive-CS-network for CMR…
The primary objectives are to describe NDTs from double pulse IES stimuli before and 20 minutes after HFS induced secondary hyperalgesia, as verified by responses to mechanical pinprick stimuli, and describe EPs of detected double pulse IES stimuli…
To assess muscle protein synthesis rates to continuous, elevated plasma amino acid availability in healthy young males
To establish whether the decrease in pulmonary function as a result of wearing a neoprene suit is caused by restriction or obstruction, and which effect is has on pulmonary volumes.
Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…
The primary purpose of this study is to enhance the understanding of the disease progression in sepsis, particularly from ICU admission to the development of DIC. This will be achieved by investigating the association between various biomarkers with…
Primary Objective:The study aims to assess freedom from AF ten years after the procedure without the use of antiarrhythmic drugs in patients who underwent thoracoscopic ablation in advanced AF with or without GP ablation. Secondary Objectives:1. To…
To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.