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PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients

The primary objective is to show that brain MRI surveillance alone is non-inferior in terms of overall survival (OS) to brain MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).

A prospective study of primary metastatic renal cell carcinoma treated with immunecheckpoint inhibitors and cytoreductive nephrectomy vs primary tumour in place

The aim of this study is to investigate whether performing a cytoreductive nephrectomy has a beneficial effect on overall survival in patients with metastatic renal cancer receiving systemic therapy using immunocheckpoint inhibitors.

Portal Pressure in Heart Failure PoP-HF: a pilot study

Primary Objective: 1. To provide data on portal pressure in a heart failure (HF) cohort without substantiated hepatopathySecondary Objective(s): 1. To provide data on the hepatic venous pressure gradient in a HF cohort without substantiated…

The effect of discontinuing estrogen containing oral contraceptives on corticosteroid-binding globulin and total cortisol concentrations

In this study we look at how long it takes for the levels of certain hormones and hormone-binding proteins to normalizediscontinuation of COC use, in particular corticosteroid-binding globulin.

Oligometastatic directed radiotherapy for patients with castration resistant prostate cancer.

The aim of the study is to investigate the effect of MDRT to the visible lesions in patients with omCRPC (up to 3 metastases and/or local recurrence) while continuing the ongoing systemic treatment. Progression is based on prostate specific membrane…

The role of serotonin in learning and decision-making: a behavioural study*

The purpose of this study is to determine and clarify the role of serotonin in cognitive processes that support decision-making. The neural processes being studied are reward learning, patience, aversive inhibition, investing cognitive effort and…

The effect of a medical grade Honey formulation (L-Mesitran®) on vaginal Ulceration due to Pessary use: a feasibility pilot study

Objective: The primary objective is to investigate the effect on vaginal mucosa damage after the application of a Medical GradeHoney formulation (L-Mesitran ®) six weeks after starting treatment in patients with pelvic organ prolapse and pessary…

Evaluation of the Feasibility of a Gamified Lifestyle Change Intervention for Patients with Atrial Fibrillation Scheduled for Catheter Ablation: GAMES4CARE.

The primary objective of this study is to evaluate the adherence to a 3-month gamification intervention integrated with a recently developed platform for continuous lifestyle monitoring (Care-On) in patients with AF referred for catheter ablation.…

Preventing liver recurrence after partial hepatectomy for intrahepatic cholangiocarcinoma using adjuvant hepatic arterial infusion pump chemotherapy - PUMP IV trial

The aim of this study is to find out whether the addition of HAIP chemotherapy with floxuridin in patients with operable iCCA is effective, i.e. the time to recurrence is longer than with standard care.