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Quantitative assessment of the clitoral sexual arousal response in pre and postmenopausal women using magnetic resonance imaging

Primary Objective: The primary objective is to study clitoral volume changes during sexual arousal in premenopausal women compared to postmenopausal women.Secondary Objective(s) are: To study whether there is an association between feelings of…

Real-time use of artificial intelligence (CAD EYE) in the colorectal cancer surveillance of Lynch syndrome patients - an international multicenter trial

Primary Objective:- To compare adenoma detection rate (ADR) with versus without real-time automated detection (CAD EYE, Fujifilm)Secondary Objectives:- To compare the size, morphology and histology of adenomas detected and resected in both arms of…

Comprehensive assessment of the long-term effects of necrotizing enterocolitis and its treatment

To determine the long-term outcome after necrotizing enterocolitis during neonatal life, regarding (pain) sensitivity, sensory processing, behaviour, executive function, scar satisfaction (in surgically treated NEC patients), and (health-related)…

Prospective rAndomized controlled tRial of Crohn*s diseAse exclusion Diet vs corticosteroIds in patientS with activE Crohn*s disease

Main objective: to assess whether CDED is superior to corticosteroids, in terms of endoscopic response, in patients with mildly to moderately active, luminal CD.

The effect of low-dose rhythmic 17-β-estradiol administration on bone turnover in postmenopausal women

To investigate the effect of low-dose rhythmic transdermal 17-β-estradiol on serum P1NP (marker of bone formation) and CTX (marker for bone resorption), versus continuous low-dose and standard-dose continuous transdermal 17-β-estradiol…

Physiological Stress 15O-H2O Total-body PET/CT protocol

The primary objective:Study the feasibility of physiological stressors and their effect in myocardial perfusion 15O-H2O Total-body PET/CT with stress adenosine as a reference in healthy volunteers and in CAD patients.The secondary objectives:1.…

Validation of a combined arm leg ergometer for assessing and training physical fitness

Our first aim is to evaluate the validity of the developed arm leg ergometer prototype during an incremental exercise test by comparing the outcomes with a regular bicycle ergometer test. The second objective is to describe the movement of…

A Dried blood spot sampling method for VANcomycin and Creatinine monitoring: Effectiveness Demonstrated in Outpatient Parenteral Antibiotic Therapy service

To investigate if dried blood spot sampling of vancomycin and creatinine leads to less outpatient visits regarding vancomycin therapy compared to conventional sampling in OPAT service.

Multiple Sclerosis treatment with Autologous Hematopoietic Stem Cell Transplantation (MS-ACT): A long-term prospective observational study in the Netherlands

To perform long-term pre-specified follow-up of patients undergoing aHSCT for refractory RRMS.

Clinical Validation of a Continuous flow Peritoneal Dialysis System with Dialysate Regeneration

Primary objective:To assess the (short-term) safety of the WEAKID nighttime system in a limited number (n=12) of patients and sessions (6 sessions per patient).Secondary objectives1. To evaluate the incidence of AE*s and DD*s other than SADE*s and…

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Timing exercise training as strategy to improve nocturnal glucose levels and substrate metabolism in men and woman with pre-diabetes

The main objective of this study is to determine whether prolonged exercise training in the afternoon (15:00-17:00 PM) differs from exercise training in the morning (07:00-09:00 AM) in improving nocturnal glucose levels in individuals with pre-…

Promoting Resilience in Youth through Mindfulness mEditation

The aim of this study is to determine if mindfulness-based early intervention reduces internalizing symptoms in help-seeking youth and prevents their development into (serious) psychiatric illnesses. In addition we will examine putative changes in…

Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy
in Mildly Reduced or Preserved EF Heart Failure

The primary objective of this clinical trial is to further evaluate the clinical efficacy of the Corvia Atrial Shunt in symptomatic heart failure patients with a left ventricular ejection fraction (LVEF) >= 40%, and elevated left sided…

ArteriaL Fluorescence Angiography for Peripheral Arterial Disease (ALFAPAD) Study

Primary Objective: 1. To determine the feasibility and clinical relevance of quantifiable parameters from intraoperative ALFA-measurements. Secondary Objective(s): 1. Determine the intraoperative applicability of ALFA. 2. Determine the effect of…

Understanding overweight and obesity: The end of average

This project therefore adopts an urgently needed comprehensive individualized approach. We characterize each participant in a large sample of individuals varying in bodyweight by their own baseline comprehensive profile, including person…

A comparative bioavailability study of a single dose of ziltivekimab formulation B in a manual syringe, formulation D in a manual syringe and formulation C in a pen-injector

In this study we will look at the blood levels of the study compound ziltivekimab. We will investigate how quickly and to what extent different compositions of ziltivekimab are absorbed, transported, and eliminated from the body. Ziltivekimab is not…

Neoadjuvant trastuzumab, pertuzumab and tucatinib without chemotherapy in HER2-positive breast cancer: the TRAIN-4 study

This study has been transitioned to CTIS with ID 2024-518192-61-00 check the CTIS register for the current data. To evaluate safety and feasibility of neoadjuvant chemotherapy-free regimen with trastuzumab, pertuzumab and tucatinib in stage II-III…

A Phase 1/2, open label, first-in-human, dose escalation and expansion study for the evaluation of safety, pharmacokinetics, pharmacodynamics, and anti-tumor activity of SAR445877 administered as monotherapy or in combination with other anticancer therapies in adults with advanced solid tumors

This study has been transitioned to CTIS with ID 2023-507141-28-00 check the CTIS register for the current data. Primary- Dose escalation: To determine the maximum tolerated dose (MTD) or maximum administered dose (MAD), recommended dose(s), and the…

A phase 1, randomized, placebo-controlled, double-blind, single center, multiple-dose, parallel trial evaluating the impact of apraglutide on gastric emptying of liquids in healthy subjects

The purpose of this study is to see if the study compound, apraglutide, has any effect on the gastric emptying of liquids in healthy subjects. Gastric emptying is the normal way in which food passes through the body, when the contents of the stomach…