Search for a trial

Drug-COated Balloon Coronary Angioplasty versus Stenting for Treatment of Disease Adjacent to a Chronic Total Occlusion - The Co-CTO Trial.

The aim of the study is to investigate the value of DCB treatment in the residual disease of the coronary artery after successful recanalization and stenting of the actual CTO body as compared with complete stenting in a randomized fashion.

Positive end-expiratory pressure levels during resuscitation of preterm infants at birth

The specific trial aim is to establish whether the use of a high, dynamic 8-12 cmH2O PEEP level strategy to support the lung during stabilisation at birth, compared with a static 5-6 cmH2O PEEP level strategy, increases the rate of survival without…

Chronotherapy in Inflammatory Arthritis (ChronIA trial): a randomized controlled trial comparing the effectiveness of morning and evening dosing of tofacitinib extended-release

This study has been transitioned to CTIS with ID 2024-517865-17-00 check the CTIS register for the current data. We hypothesize that the timing of treatment in IA, also known as chronotherapy, matters and that the efficacy of tofacitinib XR depends…

An Open-Label, Multicenter, Phase 1/2 Trial of GEN3014 (HexaBody®-CD38) in Relapsed or Refractory Multiple Myeloma and Other Hematologic Malignancies

Dose escalation phase:Primary• Determine the RP2D and if reached, the MTD of GEN3014• Evaluate the safety and tolerability of GEN3014 Secondary:• Characterize the PK properties of GEN3014• Characterize the pharmacodynamic properties of GEN3014•…

Pilot study of FAPI PET/CT for locoregional (re)staging of lymph nodes in colorectal carcinoma

To describe the accuracy of FAPI PET/CT in the detection of regional lymph node metastases in patients with colorectal cancer in comparison with standard diagnostic imaging and (in operated patients) histopathology, aiming to provide early evidence…

Transdiagnostic processes in (comorbid) anxiety disorder(s), post-traumatic stress disorder, obsessive-compulsive disorder and depression (TAPOD)

This project aims to 1) investigate transdiagnostic processes in patients with anxiety disorders, PTSD, OCD and depressive disorders with and without comorbidity, 2) relate these processes to severity of symptoms, treatment progress, and relapse.…

The Impact of Telemonitoring on correct drug Use, complications and quality of life among patients with Multiple Myeloma (MM);(ITUMM)

The main objective of the project is to study difference between compliance by pill count after 3 months by newly diagnosed multiple myeloma (NDMM) patients with an innovative e-coach, in order to improve treatment compliance by the intervention…

Investigating the immune response to COVID-19 Vaccination in Lung Transplantation patients (COVALENT study)

To investigate the humoral and cellular immune response, and the development of immunological memory to the COVID-19 vaccination in lung transplantation patients. To clarify firstly if immunity develops in these patients and secondly, if the immune…

Leiden Thrombosis Recurrence Risk Prevention: Tailored treatment after a first venous thromboembolism: (L-TRRiP study)

To determine which patients, individually classified for VTE ánd bleeding risk, will benefit from prolonged anticoagulant treatment without being unnecessarily exposed to its risks.

Evaluating the effects of acute LPS exposure on Energy metabolism and Substrate utilization as well as markers reflecting lipid and glucose metabolism: The LES trial

The main objective for the current project is to investigate the effect of acute systemic inflammation - induced by LPS exposure - on energy metabolism, measured as resting metabolic rate (RMR), in apparently healthy volunteers.

A randomised controlled trial investigating the effect of virtual reality on labour analgesia use

The aim of this study is to investigate whether VR will decrease the request for labour analgesia. Primary outcome measure:* Request for labour analgesiaSecondary outcome measures:* Patient tolerability, feasibility and satisfaction of VR use (VR-…

Personalized Use of Resources study

This study has been transitioned to CTIS with ID 2024-515542-16-02 check the CTIS register for the current data. Primary objective:The objective is to evaluate if the LCPT dose can be reduced in comparison with tacrolimus-ER and still achieve…

The efficacy of the addition of TRAstuzumab and Pertuzumab to neoadjuvant chemoradiation: a randomized multi-center study in resectable HER2 overexpressing adenocarcinoma of the esophagus or gastroesophageal junction. The TRAP-2 study.

This study has been transitioned to CTIS with ID 2024-513797-22-00 check the CTIS register for the current data. In the so-called adenocarcinoma of the esophagus, the HER2 receptor can be detected in about 15% of the tumors. Based on the phase II…

The Impact of Early Delirium Detection with DeltaScan on Management of Underlying Delirium Causes in Critically Ill Patients. A randomized controlled trial.

This randomized controlled trial aims to study the effect of implementation of EEG based encephalopathy detection (DeltaScan, Prolira, Utrecht, The Netherlands, hereafter: DeltaScan) on relevant clinical endpoints (ICU length of stay) as well as the…

A nationwide multicentre, open-label study of six months avelumab maintenance treatment in patients with locally advanced or metastatic urothelial cancer whose disease did not progress after at least 4 cycles of first-line platinum-containing chemotherapy and the opportunity to re-treat

This study has been transitioned to CTIS with ID 2024-512975-11-01 check the CTIS register for the current data. To demonstrate benefit of maintenance treatment with avelumab for a maximum of six months avelumab in increasing overall survival (OS)…

Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks - A Prospective Multicenter Study.

To evaluate the safety of IMPEDE-FX Embolization Plug and/or IMPEDE-FX RapidFill to fill a AAA sac outside of an EVAR stent graft, and the efficacy of the IMPEDE-FX Embolization Plugs to reduce the volume and/or diameter of the AAA sac and/or the…

A pilot study assessing the feasibility of a randomized controlled trial evaluating aspirin in postpartum women at risk of developing venous thromboembolism

The purpose of this pilot trial is to determine whether it is feasible to conduct a full multicentre randomized controlled trial (RCT) to determine whether low-dose aspirin (ASA) is efficacious and safe at preventing postpartum venous…

A Phase III Multicenter, Randomized, Double-Blind, Double-Dummy Study To Evaluate Safety And Efficacy Of Ocrelizumab In comparison with Fingolimod in Children And Adolescents With Relapsing-Remitting Multiple Sclerosis

This study has been transitioned to CTIS with ID 2023-506516-40-00 check the CTIS register for the current data. The primary efficacy objective for this study is to demonstrate non-inferiority of ocrelizumab compared with fingolimod

Addition of FFRct in the diagnostic pathway of patients with stable chest pain to reduce unnecessary invasive coronary angiography

To assess the impact of adding FFRct analysis to CCTA on the rate of unnecessary invasive coronary angiography (ICA) in patients with stable chest pain that have a >=50% but less than 90% anatomical stenosis on CCTA in any major epicardial…

Clinical Surveillance vs. Anticoagulation for Low-risk Patients with Isolated Subsegmental Pulmonary Embolism: A Multicenter Randomized Placebo-Controlled Non-Inferiority Trial

This study has been transitioned to CTIS with ID 2023-506943-40-00 check the CTIS register for the current data. The overall objective of this trial will be to evaluate the efficacy and safety of clinical surveillance without anticoagulation in low-…