27 results
To compare the efficacy of six cycles neoadjuvant PTC plus pertuzumab preceded by either three cycles of FEC-T plus pertuzumab or three cycles of PTC plus pertuzumab in HER2 positive breast cancerSecondary objectives• To describe the safety of the…
To investigate the hypothesis that women with uterine prolapse stage 2 or more treated by laparoscopic sacrohysteropexy will have equal or lower recurrence rate of prolapse compared to women treated by vaginal sacrospinous hysteropexy.
To assess the outcome and pattern of frontal cognitive deficits between patients with cerebellar stroke compared to frontal stroke after three months of acute ischemic stroke with several validated neuropsychological tests and questionnaire
The aim of the study is to compare transthoracic esophagectomy versus transhiatal extended gastrectomy in patients with GEJ type II tumors. It is hypothesized that esophagectomy allows for a higher rate of radical resections and a more complete…
To study the effect of voxelotor on the hemodynamics of the cerebral vasculature (CBF and CVR)
This study has been transitioned to CTIS with ID 2024-513186-39-00 check the CTIS register for the current data. Primary objective:To evaluate the efficacy of nivolumab in combination with ipilimumab in molecular pre-selected patients with…
This study has been transitioned to CTIS with ID 2022-502482-17-00 check the CTIS register for the current data. This study will evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab in patients…
This study has been transitioned to CTIS with ID 2024-511340-29-00 check the CTIS register for the current data. Primary Objective: Evaluate if testosterone replacement therapy (TRT) in (a)symptomatic testosterone deficient men with prostate cancer…
We want to compare the effectiveness of sclerotherapy and rubberband ligation when it comes to symptoms. We will secondarily consider patient satisfaction, complications and recurrences. We hypothesize that both treatments are equally effective.
To assess achieved immunity against COVID-19 across the different age groups in The Netherlands by testing a representative part of the Dutch population for the presence of SARS-Cov-2 specific antibodies in serum
Primary Objective: Assess if the structure, composition and/or barrier function of the biliary HCO3- umbrella is intrinsically altered in cholangioids and liver biopsies derived from fibrosing cholangiopathy subjects compared to non-fibrosing…
To proof feasibility and safety of direct SEMS placement for palliative treatment of perihilar cholangiocarcinoma.
The objective of this study is to demonstrate that arthroscopic synovectomy of the wrist comined with deposition of intra-articular corticosteroids (DIACS) will lead to better functional outcomes compared to intra-articular corticosteroid injection…
The objective of the study is to establish a data infrastructure to investigate the degree in which current and previous generations of young-old are characterised by healthy and successful ageing.
The goal of this study is to investigate which treatment(-s) lead to the best outcome by using existing variation of practice.
To develop a pharmacokinetic (PK) model for the relationship between dosage, blood concentration and infection site concentration, estimating covariates to determine differences in antibiotic concentrations in synovial fluid, synovial tissue and…
Phase 2 pilot-study: to examine feasible exercise dosages in patients with mCRC and collect data on preliminary effects on clinical outcomes.Phase 3 trial: to collect data on the efficacy of exercise on 1) chemotherapy dose modifications and 2)…
The primary aim of this study is to assess whether repetitive morning, daytime or pre-night spot urine sampling can accurately estimate dietary Na+ intake and to determine the number of spot urine collections that are needed. We will assess whether…
The primary objective will focus on both the difference in incidence and disease severity of COVID-19 between patients with a chronic inflammatory disease and the control group.
The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…