38 results
To compare the efficacy of six cycles neoadjuvant PTC plus pertuzumab preceded by either three cycles of FEC-T plus pertuzumab or three cycles of PTC plus pertuzumab in HER2 positive breast cancerSecondary objectives• To describe the safety of the…
To investigate the hypothesis that women with uterine prolapse stage 2 or more treated by laparoscopic sacrohysteropexy will have equal or lower recurrence rate of prolapse compared to women treated by vaginal sacrospinous hysteropexy.
To assess the outcome and pattern of frontal cognitive deficits between patients with cerebellar stroke compared to frontal stroke after three months of acute ischemic stroke with several validated neuropsychological tests and questionnaire
The objective of the study is to establish a data infrastructure to investigate the degree in which current and previous generations of young-old are characterised by healthy and successful ageing.
Primary Objective: Assess the leakage of FFP2 respirators and surgical masks in human subjects using inhalable aerosols consisting of a solution of fluorescein in water.Secondary Objective(s): (a) Study the variability in total inward leakage of…
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
The objective of this study is to characterise and validate multidimensional latent risk and resilience mental health trajectories in a trans-syndromal sample of help-seeking young people, including identifying genetic, environmental, biological,…
Investigate the effect of FMT from healthy obese donors on objective response rate (ORR according to RECIST criteria) in patients with metastasized or locally advanced NSCLC receiving standard of care first-line immunotherapy with or without…
The primary objective of this study is to compare the mean binocular DCIVA at 66 cm under photopic conditions 3 months after cataract surgery, in a series of patients, who previously underwent myopic laser surgery, bilaterally implanted with the non…
Primary Objective: To investigate motor developmental outcome at school age of children with CHD compared to typically developing peers.Secondary Objective(s): - To investigate neurodevelopmental outcom eat school age on several developmental…
Primary Objective: • To determine the clinical Progression Free Survival (cPFS) in our study cohort of patients with mCRPC and 68Ga-PSMA-PET/CT selected bone-only disease (PET-bone only group). The cPFS will be compared to the cPFS of patients with…
The objective of the study is to assess the effect of music on postictal agitation when played peri-interventionally for patients undergoing electroconvulsive therapy for severe depression.
The primary aim of this study is to assess the feasibility of EM-navigation for percutaneous liver ablation.
To enhance our knowledge of the molecular nature, induction and regulation of the autoantibody and B cell response involved in/responsible for the induction of VITT
Gain insight into the health and health-related factors in adults with intellectual disabilities.
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…
The main objective of this study is to determine the maximum tolerated dose (MTD) of 2-fraction boost MRI-guided radiotherapy (MRgRT) for patients with SCC following CROSS therapy. The secondary objectives are feasibility, non-dose limiting toxicity…
This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden UniversityMedical Centre. If proven successful, home monitoring…
The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…
Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…