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The effects of intravenous TRH administration on brown adipose tissue activity in healthy, lean men.

To investigate whether BAT tissue can be activated by intravenous administration of TRH. Secondary objectives are to determine whether intravenous TRH increases the degree of cardiovascular sympathetic stimulation and the response of skin…

Effect of donor human milk on severe infections and mortality in VLBW infants, a double blind randomized controlled trial

To determine whether (supplemental) human donor milk has beneficial effects (in terms of reduction of infectious episodes and mortality) when compared to (supplemental) preterm formula during the first 10 days of life in VLBW infants. Amendement ESS…

Memory formation under stress in humans - the importance of the Mineralocorticoid Receptor

The main objective is to investigate the role of MRs in memory acquisition and recall during stress and non-stress conditions. Specifically, we are interested in two domains of memory, spatial and fear memory. Secondary objectives are to determine…

Nociceptive-Level (NoL)-guided analgesia versus standard practice during general remifentanil/propofol anesthesia in ASA 1-3 patients

To guide the analgesic component of anesthesia using the Nociceptive Level (NoL) index in ASA 1-3 patients under general anesthesia for elective abdominal surgery.

Baseline Dopamine Dependent Drug Effects of Methylphenidate and Sulpiride on Brain and Behaviour: A PET, Pharmaco-fMRI Study

We aim to develop a proxy-model of baseline dopamine based on machine learning methods which would provide us with behavioural predictors of the effects of dopaminergic drugs on brain and cognition that maximally generalize to new participants.

The effect of arabinose on sucrose-induced glycemic response and glycemic kinetics as measured by a dual stable isotope methodology

To compare the digestion and absorption kinetics following the ingestion of sucrose plus arabinose versus sucrose only in healthy, young subjects.

Brain and glycemic responses to soft drinks with different sweeteners (SWEETBRAIN)

To determine changes in brain activity in responses to the ingestion of flavored waters sweetened with either the nutritive sugar sucrose or different low-caloric sweeteners.

Protein requirements in healthy adult men as assessed by the Indicator Amino Acid Oxidation (IAAO) technique: a replication study

Replication study to assess dietary protein requirements in young, healthy men.

The effect of 12-week supplementation with AstaPure® on skin-aging and muscle function in postmenopausal women (<=70 y)

The primary objective is to examine the effect of twelve weeks supplementing daily one AstaPure® Oleoresin capsule on trans epidermal water loss (TEWL) in postmenopausal women. The secondary objectives are to investigate the effects on other skin,…

Dietary nitrate to preserve cardio-metabolic health during bedrest.

The primary objective is to evaluate the effectiveness of dietary nitrate in reducing muscle atrophy induced by bedrest. Secondary objectives include assessing its impact on insulin resistance, muscle strength, and cardiovascular function.…