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The Role of the Intestinal Barrier Function in Liver Cirrhosis

Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…

Vocal cord pathology after short term intubation

First objective; to document the existence and to categorize vocal fold pathology after short term intubation and to study voice related patient complaints after short term intubation. Second and third objective; to study the pattern/type of injury…

The effect of weight loss through a low calory diet on exercise induced bronchoconstriction in children with asthma and moderate overweight.

To analyze the relation between reduction in BMI and reduction in the exercise induced fall of FEV1 after a diet-period of 6 weeks. Secondary we analyze the relation between reduction in BMI and the recovery of the lungfunction to baseline (measured…

HEalthy LIfe in an Urban Setting (HELIUS): a prospective cohort study on health and health care utillization among different ethnic groups in Amsterdam

The general objective of HELIUS is to describe (trends in) patterns of chronic conditions across six ethnic groups over time, and to unravel the causes of (the unequal burden) of chronic diseases across ethnic groups, with an emphasis on…

Pelvic versus peripheral steroid levels in postmenopausal patients with and without endometrial hyperplasia or carcinoma.

The aim of the study is to investigate the local levels of steroid-hormones compared to the peripheral levels in postmenopausal patients with endometrial hyperplasia, endometrial carcinoma and postmenopausal women without these diseases. This will…

Effect of N3-polyunsaturated fatty acids on peripheral insulin sensitivity

to measure peripheral insulin sensitivity and intramyocellular concentrations of different FA metabolites (ceramide, gangliosides, diacylglycerol and triacylglycerol) known to interfere with the insulin signalling cascade during infusion of…

Interoceptive fear conditioning by using interoceptive stimuli and CO2 enriched air in healthy participants.

The aim of the present study is to establish intero-interoceptive fear conditioning in healthy participants in a differential conditioning paradigm. We want to make use of *real* interoceptive conditioned stimuli: a low respiratory load and small…

Vitamin D levels in adults with non-atopic asthma: a case-control study

To compare the levels of vitamin D in subjects with non-atopic asthma to those in subjects with atopic asthma and those in healthy non-atopic subjects

The effect of treatment with high dose vitamin D on airway inflammation in non-atopic asthma.

Primary Objective: To investigate the effect of supplementation of a single high dose of vitamin D (400.000 IU) on 1. the percentage of neutrophils in induced sputum, in non-atopic asthmatic patients with neutrophilic airway inflammation (…