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The STAP-study: Skills training and traumafocused treatment in multiple interpersonal traumatized adolescents with PTSD.

The randomized controlled trial (RCT) will be performed at Karakter Child and Adolescent*s Psychiatric Hospital and will be implemented at all locations, spread out over three provinces in The Netherlands. The project aims:1. To explore the…

rational rehabilitation in therapy resistant PTSS

to reduce ptsd symptoms and psychological suffering in general, and to improve quality of life

The Dutch ICH Surgery Trial pilot study; minimally-invasive endoscopy-guided surgery for spontaneous intracerebral hemorrhage

1. To study safety, feasibility and technical effectiveness of minimally-invasive endoscopy-guided surgery for treatment of supratentorial ICH; 2. To estimate the potential effect of minimally-invasive endoscopy-guided surgery on functional outcome…

The TAPS Trial;Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence: a multicenter open label randomized controlled trial

The aim of this trial is to investigate whether fetoscopic laser surgery improves the outcome for TAPS twins as compared to the control group (standard care consisting of expectant management, IUT, preterm delivery). The hypothesis is that…

Treating the compromised hearts of patients with Rheumatoid Arthritis * Can we repair the damage?

Primary Objective: To investigate diastolic LV dysfunction before and after 6 months anti-inflammatory treatment with TNF blockers in patients with RA, assessed by exercise-stress echocardiography.Secondary Objective: To investigate whether systolic…

Follow-up of patients with an ankle arthrodesis

The main aim of this study is to investigate if patients that received an ankle arthrodesis, have arthritis in the adjacent joints (subtalar joint and talonavicular joint). Furthermore, we would like to study (1) the amount of increase of arthritis…

The Zen Garden: A feasibility randomized controlled trial of an m-health tool for blended Competitive Memory Training for self-esteem problems

Goal of this first pilot study is to explore the feasibility, acceptability and indications of clinical effects of the blended version of the COMET protocol for self-esteem, in comparison with the standard protocol of COMET therapy. While the…

A Phase 3 Randomized, Double-blind, Placebo-controlled, Multi-center Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-care Treatment in Adolescent, Adult, and Elderly Non-hospitalized Subjects With Influenza A Infection who Are at Risk of Developing Complications

The primary objective is to evaluate superiority of pimodivir (Pi) in combination with standard-of-care (SOC) treatment (tmt) compared toplacebo in combination with SOC treatment, with respect to the time to resolution of influenza-related symptoms.

Sleep Measuring with Non-Invasive Applications: the HealthBed Database

Sleep Medicine Center Kempenhaeghe has a unique opportunity to combine clinical PSG with different advanced non-invasive sleep monitoring techniques as mentioned in the former paragraph. In the center, data are currently obtained in a cohort of…

A treatment components analysis of a stepped-care, CBT based treatment for adults with tinnitus: a replicated single-case experimental approach

Primary Objective: To investigate, in a series of studies, what effect the elements of CBT for tinnitus have on tinnitus distress. Study 1: The objective of study 1 is to examine the effects of audiological assessment, psychological assessment and a…

An open-label randomised cross-over study to evaluate the albuminuria lowering effect of dapagliflozin, exenatide and their combination in patients with type 2 diabetes

The main objective of the study is to determine the albuminuria lowering effect of the GLP1-RA exenetide, SGLT-2 inhibitor dapagliflozin and their combination in patients with type 2 diabetes and micro- or macroalbuminuria.Secondary objectives are…

Optimization of pulmonary vein isolation by using grid visualization

To study the effect of grid visualization during PVI on procedure times, to study the effect of grid visualization on acquiring direct isolation after encircling the pulmonary veins (*single round* ), to study the effect of grid visualization on the…

The effect of Virtual Reality as a source of information on anxiety, pain and patient sattisfaction in children that need to undergo an Intravenous catheterplacement.

In a randomised setting we want to investigate wheter we can reduce anxiety and pain in children that need an IV catheter by using a 360 Virtual Reality video in preparation of the actual needle placement.

Family Empowerment (FAME): A pilot implementation and evaluation of multi-family groups as a secondary prevention program for asylum seeker families.

This study concerns a pilot implementation and evaluation of FAME. - It aims to provide an initial indication of the efficacy of FAME in families in two living conditions: asylum centers and family locations. It is hypothesized that FAME has a…

Magneto-encephalography (MEG) to image the brain*s role in the analgesic effects of Spinal Cord Stimulation (SCS), an explorative study

Image with magneto-encephalography (MEG) the supraspinal effects of conventional and burst SCS settings in patients who already have a spinal cord stimulator, to study the analgesic mechanisms of action of SCS and to improve the treatment of chronic…

Pilot to validate in vivo 2-HG MR spectroscopy in low grade gliomas

Primary goal is to investigate if the 2-HG peak on in vivo MR spectroscopy correlates with the ex vivo IDH mutation and 2-HG concentration in patients with a low grade gliomas.

Treatment with Recombinant human Interleukin 1 receptor antagonist (Anakinra) in patients with Anaplastic Thyroid Cancer: a proof of concept study

To investigate the efficacy of treatment with human recombinant IL1Ra (rhIL1Ra, Anakinra) in patients with ATC in terms of improved health related quality of life (HRQoL), tumor progression and Overall Survival (OS). Secondary objectives: To…

microcirculatory perfusion in living kidney donors

To study microcirculatory perfusion in living kidney donors before and after donation.

A multicenter, randomized, open label, efficacy assessor-blinded study of risankizumab compared to secukinumab for the treatment of adult subjects with moderate to severe plaque psoriasis who are candidates for systematic therapy.

The objective of this study is to evaluate the efficacy and safety of risankizumab compared with secukinumab for the treatment of adult subjects with moderate to severe plaque psoriasis who are candidates for systemic therapy.

A Phase III, randomized, multicenter, parallel-group,
non-inferiority study evaluating the efficacy, safety, and
tolerability of switching to dolutegravir plus lamivudine in
HIV-1 infected adults who are virologically suppressed

PrimaryTo demonstrate the non-inferior antiviral activity of switching to DTG +3TC once daily compared to continuation of TBR over 48 weeks in HIV-1 infected, ART therapy (ART)-experienced, virologically suppressed subjectsSecondary- To demonstrate…