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rational rehabilitation in therapy resistant PTSS

to reduce ptsd symptoms and psychological suffering in general, and to improve quality of life

Clinical and cost-effectiveness of group schema therapy for
complex eating disorders: the GST-EAT study

The aim of the current project is to test the clinical and cost-effectiveness of GST for patients with an ED (i.e., anorexia nervosa, bulimia nervosa, other specified), that are not likely to benefit from CBT-E. The study will focus on those…

Brain and glycemic responses to soft drinks with different sweeteners (SWEETBRAIN)

To determine changes in brain activity in responses to the ingestion of flavored waters sweetened with either the nutritive sugar sucrose or different low-caloric sweeteners.

A First-in-Human, Double-Blind, Randomised, Vehicle-Controlled Phase I/II Proof of Concept Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BEN2293 in Patients with Mild to Moderate Atopic Dermatitis.

PrimaryThe primary objective of this study is to assess the safety and tolerability of BEN2293, administered as multiple topical doses to increasing body surface area (BSA), in patients with mild to moderate AD.SecondaryPharmacokinetics· To…

Dietary oxalate absorption and microbiome diversity in patients with nephrolithiasis and hyperoxaluria: a stable isotope technique.

With this study, we aim to gain insight in the influence of dietary oxalate on urinary oxalate levels by quantification of the intestinal oxalate absorption in patients with recurrent idiopathic calcium oxalate stones, primary hyperoxaluria, and…

Evolving to an integrated smart self-assessment *Fatigability in Outcomes to monitor Resilience Targets in Older persons* (FORTO) measurement & monitoring platform.

This study aims to evaluate the predictive ability of the muscle fatiguability test to predict recovery in older adults admitted to the department of geriatric medicine. Recovery is defined as length of stay, daily functioning after 3 and 6 months…

Predicting Response In Cervical intraepithelial neoplasia to Topical Imiquimod treatment (PRedICT-TOPIC)

This study aims to validate the potential of immune related biomarkers to predict the clinical response of patients with primary cHSIL to imiquimod and aims to explore the value of these immune biomarkers in recurrent/residual cHSIL to predict…

An explorative and experimental study to assess the feasibility, acceptability and effectiveness of four imagery intervention techniques in the treatment of auditory vocal hallucinations

The main objective of this study is to assess the feasibility, acceptability, and effectiveness of four imagery intervention techniques adapted from the protocol of Holmes (2019) for auditory vocal hallucinations. We are primarily interested in…

Electrophysiological markers of cortical excitability to predict response to treatment with anti-seizure medication

To address the potential of cortical excitability measures using TMS-EEG/EMG to differentiate between responders and non-responders to ASM in people with refractory focal epilepsy. The secondary objectives are to validate visual evoked potentials (…

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing cystectomy. The ENHANCE randomized controlled trial.

To study the effectiveness of a multimodal prehabilitation program preceding radical cystectomy in reducing the number and severity of perioperative complications within 90 days, shortening the length of hospitalization and reducing the number of…

Comparison of prenatal and postnatal cardiac function assessed by echocardiography using pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between foetuses/neonates with a structural heart disease, with an fetal growth restriction (FGR) and healthy fetuses/neonates

Comparison of prenatal and postnatal cardiac function assessed by echocardiography using 2-D, 3-D, pulsed wave Doppler, Tissue Doppler and (blood) speckle tracking (focussing on strain and strain rate) between fetuses/neonates with structural heart…

A Randomized, Double-blind, Placebo-controlled, Single Ascending Dose and Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of REC-3964 in Healthy Subjects

REC-3964 is a new investigational drug, meaning that it has not yet been approved or marketed in the Netherlands or anywhere else at this time.In this study, REC-3964 is investigated in humans for the first time. REC-3964 has not been used by humans…

A randomized, double-blind, placebo-controlled, parallel-group, phase 2 study to evaluate the safety and efficacy of CT1812 in subjects with mild to moderate Alzheimer's disease

The purpose of this study is to evaluate the safety and efficacy of two doses of the study drug CT1812 per day for six months in subjects with mild to moderate Alzheimer's disease. CT1812 will be compared with a placebo. A placebo is a product…

Towards accurate screening and prevention (2-ASAP): PTSD risk screening study

The primary objective of this study is to derive and externally validate a prognostic screening instrument to predict individual risk to follow an adverse PTSD symptom trajectory over the course of one year following trauma based on self-report…

Alternative dosing scheme of pomalidomide 4 mg every other day versus pomalidomide 2 mg and 4 mg every day: reduction in costs, same efficacy? A PKPD bioequivalence pilot study - the POMAlternative study

Primary objectiveTo assess in which percentage of patients the AUC/MIC ratio is above the target of 270 µg*h/L and Ctrough is above the target EC50 (2.7 µg/L) during usage of pomalidomide 4 mg every day, pomalidomide 4mg every other day, and…

A multicenter, open-label extension study to investigate the long-term safety of FAB122 in patients with Amyotrophic Lateral Sclerosis.

To evaluate the long-term safety of FAB122 in patients with ALS.

A randomized, placebo-controlled, double-blind, parallel-group Phase 2a exploratory study with placebo run-in to investigate PK/PD effects, safety, tolerability and pharmacokinetics of REM0046127 oral suspension compared with placebo in subjects with mild to moderate Alzheimer's disease

• To assess the tolerability and safety of the investigational medicinal product

Dutch ICH Surgery Trial; minimally invasive endoscopy-guided surgery for spontaneous intracerebral hemorrhage

1. To study whether minimally invasive endoscopy-guided surgery, in addition to standard medical management, for the treatment of spontaneous supratentorial ICH performed within 8 hours of symptom onset, improves functional outcome in comparison…

First-in-human, randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic effects of Apta-1.

Part ATo evaluate the safety and tolerability of single and split intravenous doses of Apta-1 in healthy volunteers.Part BTo evaluate the safety and tolerability of split intravenous doses of Apta-1 after LPS infusion in healthy volunteers.

A randomized, double-blind, placebo-controlled, Phase III trial to
evaluate the efficacy and safety of intra-articular injections of
RTX-GRT7039 in adult subjects with pain associated with osteoarthritis of the knee

Primary objective:Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.Secondary objective:• Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.• Demonstrate the efficacy of…