89 results
Our primary objective is to investigate the effects of methylphenidate on language comprehension and creativity, and to link these effects with the effects of methylphenidate on working memory. Our secondary objective is to establish the relation…
The primary objective is investigating the influence of Virtual Reality distraction on pain. The secondary objectives were, investigating if (1) the executive functions and catastrophizing thoughts influence the effect of VR as pain relief; (2) the…
The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…
1. Determine body composition of MD patients;2. Determine physical function of MD patients;3. Determine the association of body composition and physical function of MD patients.
The main aim of the ZELF-i project is to investigate the effectiveness of self-monitoring and personalized feedback as an add-on tool in the treatment of depression. By starting directly after intake, patients can make the most out of the usual…
To guide the analgesic component of anesthesia using the Nociceptive Level (NoL) index in ASA 1-3 patients under general anesthesia for elective abdominal surgery.
- Investigate the safety and tolerability of single ascending doses of DNL104 in healthy volunteers.- Characterize the pharmacokinetics of DNL104 in plasma, CSF, and urine.- Characterize the effect of a high fat meal on the pharmacokinetics of…
To study the effects of collagen peptide supplementation on knee joint discomfort in active elderly with activity-related knee discomfort.
Our primary aim is to tackle the factors of frailty in an early phase, which is possible in elective planned surgery. We hypothesise that optimal preparation, starting 5 weeks before surgery, will reduce the incidence of delirium from 15 % to 7.5…
The main objective of the study is to construct reference curves for fetal bladder diameters and volume in the second and third trimester of pregnancy. Moreover we will investigate the variation in the dimensions of renal pelvis in relation to the…
Primary Objective: To investigate the effect of food order on postprandial blood glucose levels in children with type 1 diabetes, using 2 isocaloric meals. A standard meal with all macronutrients (carbohydrates, proteins and fat) combined will be…
To investigate the predictive factors for sarcopenia in high risk surgical oncological patients undergoing a CRS + HIPEC procedure. The secondary goal is to investigate the predictive factors for malabsorption and the incidence of anastomic leakage…
Primary objective:-To investigate the safety and tolerability of JNJ-54175446 in subjects with major depressive disorder.Secondary objectives:-Investigate the effect of JNJ-54175446 versus placebo on total sleep deprivation-induced changes in…
The study aims to extend current insights into the effectiveness of nudging by examining neural correlates in two specific areas important for choice architecture; the role of social influences, and the role of colour cues in product evaluation and…
The purpose of the study is to investigate how quickly and to what extent JNJ-53718678 is absorbed, distributed, metabolized (broken down) and eliminated from the body. JNJ-53718678 to be administered will be labeled with 14-Carbon (14C) and is thus…
Primary Objective•*To evaluate the relative oral bioavailability of SMV, ODV, and AL-335 when administered as different concept fixed-dose combination (FDC) formulations compared to the single agents when administered together, all under fed…
Primary ObjectiveTo evaluate the effect of a single 84-mg dose of intranasal esketamine compared to placebo, on next day driving performance and repeated administration of 84 mg intranasal esketamine on same-day driving performance as assessed by…
The objective of the study is to compare free-hand needle placement with navigation guided needle placement.
To monitor and describe the natural motor learning of handrim wheelchair propulsion during usual care in a Dutch spinal cord injury rehabilitation center. Motor learning is operationalized as change in mechanical efficiency, propulsion technique and…
To determine the difference in the amount (average per patient) of clinical check-ups performed in the hospital for the DBS and the non-DBS group. To compare the total economic burden for the intervention and non-intervention groups from a societal…