123 results
The purpose of the study is to systematically document the signs and symptoms of sexual abuse in infants and very young children and the short-, medium-, and long-term effects of the abuse, including the effects of the persistence of pornographic…
We propose to set up a bladder cancer infrastructure within the logistic framework of the NCR. Patients with HR-NMIBC, MIBC and mBC will be prospectively recruited for ProBCI with longitudinal assessments from primary diagnosis until death. Main…
The primary objective of the study is to assess the longitudinal effects of differences and changes in renal function at CKD stage 3-5 on physical functioning. The secondary objectives of the study are to assess the longitudinal effects of…
To replicate the DEPREDICT algorithm (formed from external cohorts/datasets) as a valid tool for prediction of AD treatment non-response, we aim to recruit 80 patients who are treat-ed with an SSRI or SNRI and are eligible and willing to have an MRI…
The aim of the RADICES study is to investigate the effects of a 12-week exercise and nutrition intervention for patients with metastatic oesophageal or gastric cancer. The intervention will be completely tailored to the condition and nutritional…
Generate prospective follow-up data to increase our understanding of this rare disease.
Primary objective • In this study we will investigate whether biochemical imaging of change (Δ, figure 1) in the metabolic phospholipid ratios of PME and PDE between baseline and after 2 weeks of therapy are predictive for progression free survival…
2.1 Primary Objectives• To identify brain activation evoked by sensation in response to bladder filling in patients with an implanted sacral neurostimulator as a treatment for overactive bladder (OAB), compared to a baseline in OAB patients without…
The current study aims to obtain a better understanding of glymphatic dysfunction in dementia of the Alzheimer*s type and its preclinical stages.The main objective of this study is to improve our understanding of the potential link between…
To determine which biological processes play an essential role in immune-pathological changes in vitiligo skin depigmentation.
This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.
The study aims to determine the feasibility and diagnostic accuracy of quantitative Magnetic Resonance Imaging (MRI) techniques for determining the presence of portal hypertension in patients with severe liver disease. The secondary objectives are…
Our main aim is to test the effectiveness of a personalized sport intervention, which aims to promote social integration through sport activities in the community.
To assess whether adjuvant chemotherapy can be safely omitted in patients with pathological stage I (pT1a/b/cN0) TNBC and a high sTIL score (defined as >=50% for patients <40 years at the time of TNBC diagnosis; >=75% for…
Testing and implementing Stepped care 18+ in practice.
The primary research objective is to assess the feasibility of fetal CMR in all academic centers in The Netherlands.The second research objective of the study is to investigate the diagnostic capacity of fetal CMR for aortic and pulmonary CHD and…
The purpose of this clinical study is to collect safety and efficacy data of the VDyne System to support Conformitè Europëenne (CE) Mark of the VDyne System.
The primary objective:- To investigate the feasibility of capturing in-vivo cross section images of the bladder wall in bladder cancer patients with the OCT catheter.Secondary objectives:- To evaluate the duration of the OCT measurements. - To…