26 results
We hypothesize that VOCs hold potential as a non-invasive screening tool for detection of colorectal neoplastic lesions in Lynch syndrome. Faecal composition of microbiota as well as amino acids and proteins might be other potential non-invasive…
Gender affirming hormone treatment can cause changes in the oral health and oral microbiome of the participants
The overall aim of the current study is to improve quality of life in patients with cognitive disorders. First, by improving diagnosis of PTSD symptoms in these patients. Second, we will estimate comorbidity rate of PTSD in clinical populations of…
Determine the frequency, phenotype and function of disorder-related immune cells, or levels of immune molecules in skin and peripheral blood of patients with inflammatory skin diseases, during the active phase of disease prior to and/or at any time…
Objective: Foods consisting of locally grown seasonal vegetables, beef, whole milk and dairy butter with a balanced composition of omega 3 and 6 fatty acids and a wide range of essential micronutrients positively influences the developing immune…
Evaluation of the effect of different treatment thresholds in a clinical pathway for children with acute asthma who are treated with supplemental oxygen
The objective of this prospective randomized controlled trial is to compare the outcomes of arthroscopic primary repair of proximal ACL tears with the current gold standard of ACL reconstruction.
Establishing efficacy and safety of the electrodes and implantable pulse generators (IPGs), which are used for deep brain stimulation (DBS) in patients with obsessive-compulsive disorder (OCD).
We aim to perform an in-depth investigation into the role of the mucosal immune response in the pathogenesis of rheumatoid arthritis. Our objectives are to study the presence of RA-specific autoantibodies and several other biomarkers (cytokines,…
To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes.
The aim of this study is to assess the efficacy of MR-HIFU as a treatment modality for desmoid-type fibromatosis (DTF).
Primary Objective:To establish the maximum tolerated healthy liver-absorbed dose of 166Ho-microspheres in patients with HCC who receive RL as a bridge to resection.Secondary Objective(s): 1) To establish dose-response relationships between:a. The…
The purpose of the study is to test the feasibility of image-guided navigation during robot-assisted sentinel node dissection.
Primary objective: 1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
This study investigates how well the combination of the two drugs, zibotentan and dapagliflozin, works for the treatment of chronic kidney disease in patients. We compare the effect of zibotentan and dapagliflozin with the effect of a placebo. The…
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
The main objective of this study is to determine the efficacy of STAIRS. The secondary objectives are: (1) to investigate the association between improved personal recovery and depression relapse and (2) to gather qualitative insights into the…
The main objective of this project is to build a comprehensive model for a better predictio n of progression in MS, as a first step to move towards personalized prediction. Secondary objectives aim to study specific aspects of underlying mechanisms…
The aim of this study is to determine the effectiveness of N-sleeve in terms of a reduction of GERD in morbidly obese patients, compared to LRYGB.
To study the most relevant outcome measures and a cost-effectiveness analysis of laparoscopic PIRS technique compared to open hernia repair in infants aged 6 months to 16 years of age with a primary unilateral inguinal hernia