31 results
With this prospective registry we aim to evaluate the outcome of patients with a T2-T3 primary melanoma and minimal SN tumor burden, treated by CLND or nodal observation:* The main objective is to determine if T2-T3 melanoma patients with minimal SN…
1. We will recruit 30 probands who meet DSM-IV inclusion criteria for a primary psychotic disorder or mood disorder with psychotic features: schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post…
To explore the clinical role of infection and inflammation in lumbar and cervical radiculopathy.
Compare the effect of three different RBC transfusion strategies* (Standard of care (SoC), SoC+1 and SoC+2**) on heart rate in a population of chronically transfused patients (with on average at least 1 RBC transfusion each 8 weeks as personal…
We aim to describe and identify distinct daily glucose patters (DGP) in the general population that are related to increased risk of diabetes and diabetes related micro- and macro-vascular complications using the flash sensor technology through the…
Primary Objective:To characterize a cohort of STXBP1-encephalopathy patients in a standardized, integrative manner, including in-depth clinical profile characterization and EEG recordings. Moreover, for a subgroup of patients, iPSC-derived induced…
The aim of this study is to combine acoustic characteristics from spontaneous speech and results from tests at different linguistic levels e.g. the Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in speech are most…
Primary objective:- To determine the difference in mean dose (Gy) to pelvic bones (whole pelvic contour), and the difference in the mean V15Gy-bowelbag volume in cc (according to EMBRACE bowel bag definition) between photon and proton therapy in…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
To assess the efficacy of early mechanical left ventricular unloading and standard of care (inotropes/vasopressors) versus inotropes/vasopressors alone (standard-of-care) in patients with ADHF and signs of cardiogenic shock.
This study has been transitioned to CTIS with ID 2024-512639-58-00 check the CTIS register for the current data. ____________________PRIMARY OBJECTIVESFor Parts 1 and 2: To assess the safety and tolerability of BNT142 at all dose …
Primary objective:To identify common mutations or other genetic alterations and their potential as therapeutic targets in granulosa cell tumours, by studying human granulosa cell tumour specimens and establishing 3D organoid cell cultures derived…
To evaluate the efficacy and safety of oral masitinib versus placebo in the treatment of patients suffering from Smouldering or Indolent SevereSystemic mastocytosis with handicap unresponsive to optimal symptomatic treatment.
The major objective of this clinical investigation is to demonstrate safety and effectiveness of the ablation system (OMNYPULSE* Bi-Directional Catheter and TRUPULSE* Generator) when used for isolation of the atrial PVs in treatment of subjects with…
To compare the efficacy of POEM to the efficacy of endoscopic pneumodilatation as initial treatment of symptomatic idiopathic achalasia in children. The primary outcome measure is the need of retreatment (i.e. EBD, LHM, POEM or intra-sphincteric…
Aim of the study is to show the feasibility of pneumatic tube transport of thrombocyte concentrates. The efficacy will be measured by thrombocyte increment (CCI) and thrombocyte funtion analysis. This shall lead to routine transportation of TC*s to…
In this clinical project we aim to fill in gaps in our knowledge on muscle fiber contractility, auto-immunity and myositis: 1) How responsive is human muscle fiber contractility following standard of care immunosuppressive treatment? 2) Is the…
To compare the effectiveness of a generalist approach (GIT-PD) to specialized psychotherapy for personality disorders (PD) and to predict for which individual patient generalist treatment is not inferior to specialist treatment.
the primary aim is to determine the effect of thawed deep-frozen platelets re-suspended in thawed deep-frozen plasma versus room temperature stored platelets in platelet additive solution for transfusion on the percentage of patients with surgical…
The primary objective of this study is to assess the safety and performance of the ABLE Daily to perform ambulatory functions in home and community settings for people with spinal cord injury.The secondary objectives are to assess the impact of the…