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Characterizing Rate of progression in USHer syndrome type 2 (CRUSH) study

Main objective: To map the natural course of the visual and hearing deterioration in Usher Syndrome type 2 for upcoming genetic therapy studies.Secondary Objective 1): To determine a. the necessary type of (combined) examinations, b. the sample size…

Healthy volunteer studies for development of imaging techniques for motion management in MR-guided adaptive radiotherapy

Development of new imaging techniques for MR-guided motion management in the presence of respiratory motion

Development of blood-based monitoring techniques in lymphatic malignancies

Development of blood-based monitoring techniques for treatment response evaluation and diagnostics in lymphoid neoplasms, including HL and NHL by using extracellular vesicle and cfDNA techniques for biomarker discovery, assay development and…

Amyloid PET in patients with carotid occlusive disease

We aim to use quantitative [18F]Florbetaben PET to investigate a potential lateralized distribution of cerebral amyloid-β deposition in patients with COD. To validate the assumption that the hypoperfusion is lateralized, we use relative perfusion (…

Imaging tumor-infiltrating CD8+ T-cells in non-small cell lung cancer upon neo-adjuvant treatment with Durvalumab (MEDI4736).

The overall aim of this study is to demonstrate increase of tumor-infiltrating CD8+ T cells in non-small cell lung cancer during neo-adjuvant treatment with durvalumab (MEDI4736).

Test-retest repeatability of quantitative radiomics features of FDG PET/CT studies in patients with diffuse large B cell lymphoma

At the moment it is unknown which radiomics features are robust against variations in image characteristics. The objective of this study is to check the robustness of radiomics features, and to investigate wheter specific pre- and postprocessing…

Diagnostic Accuracy of Ultrasound Indices in pediatric IBD

To determine the accuracy of US for detecting disease activity in paediatric patients with IBD and to develop an easy-to-use and accurate US-activity index that can accelerate and improve clinical management by reducing the need for gastrointestinal…

Basophil Activation Test cow's milk for replacement of the food challenge test

Determination of the (cost)effectiveness of the replacement of the expensive, risky and time-consuming food challenge test bythe Basophil Activation Test (BAT) for the diagnosis of an IgE-mediated cow*s milk allergy in children.

Clinical assessment of women with Persistent Genital Arousal Syndrome (PGAS) by quantitative sensory testing (QST) and cornea confocal microscopy (CCM)

The primary objective of this study is to study signs of small fiber neuropathy in PGAS patients compared to healthy controls.

Hemodynamic characterization in hypertrophic cardiomyopathy after septal myectomy +/- mitral valve repair: a 4D-flow MRI study

Although this procedure has been performed for more than 20 years and clinical results after myectomy combined with AMVLE are satisfactory, very little is known about the effect of surgical myectomy intervention on the blood flow through the aortic…

TORBO: Research in Twente on Recurrences after Pelvic Organ Prolapse Surgery

Objective: This protocol describes a framework that will be used to create different studies. The general primary and secondary objectives of this protocol are stated below:Primary objective: Investigate the effect of surgery on the position and…

Traumatization and PTSD in people with Mild Intellectual Disabilities or Borderline Intellectual Functioning (MID-BIF) and*severe*behavioural*problems: screening, assessment and treatment.**

The present study has several aims. The first aim is to adapt and validate a trauma screener suitable for people with MID-BIF (Study #1), with the hypothesis that*the adapted screener would be a valid screening instrument (AUC of at least 0.8) for…

OPtimal stEnt deployment stRategy oF Contemporary sTents

Primary objectiveThe primary objective is to evaluate whether a standard pre- and postdilatation of the modern DES results in a more optimal stent implantation compared to DS as evaluated by OCT in patients with stable coronary artery disease.…

Value of MRCP+ And Liver Multiscan in the management of Dominant strictures in primary sclerosing cholangitis

Primary Objective: Assess the ability of MRCP+ and LMS to detect change in total biliary volume and cT1 value, 8 weeks after endoscopic treatment of dominant strictures, by a clinical decision rule.Secondary Objective(s): Assess natural course of…

Early prediction of treatment response in children with Inflammatory Bowel Disease with Intestinal Ultrasound

To assess the early predictive value of IUS for therapy response in children with IBD (new onset or known IBD).

Intraoperative arthroscopic near-infrared fluorescence imaging of the vascular perfusion of the meniscus in patients treated with meniscal repair

To investigate the possibility of NIR fluorescence intra-operative angiography of the meniscus using ICG in patients undergoing arthroscopic meniscal repair.

Screening gestational diabetes: glucose curve versus oral glucose tolerance test

The primary objective is to compare the glucose curve with the OGTT, as a screening test for GDM.The secondary objective is to see if GDM treated after screening either with the glucose curve or with the OGTT, can predict perinatal complications and…

Biomarkers in synovial fluid and serum as an indicator for the health status of the knee joint.

To evaluate whether we can determine the health status of the joint by measuring biomarker levels using a newly developed assay by the University of Twente based on the multiplex measurement of a panel of relevant biomarkers using Surface Plasmon…

Exploring an alternative pre-operative sentinel lymph node mapping method using a Magnetic tracer and MRI for melanoma patients

The primary objective of this study is to evaluate the feasibility and diagnostic accuracy of pre-operative MRI scanning using SPIO compared to lymphoscintigraphy (LS) and single-photon emission computed tomography/computed tomography (SPECT/CT)…

Exploring Metabolic Maturation in the Extremely Preterm Brain at Term Equivalent Age: EMMA study.

We will combine four 7 Tesla MRI markers in extremely preterm infants (MRSI; SWI; PC-MRI; ihMT) to assess (1) if they can predict outcome until 2 years of age; (2) if they are of added value to 3 Tesla prematurity (Kidokoro et al., 2013) and (3) if…